User profiles for Qianben Wang
 | Qianben Wang, Ph.D.Professor of Pathology and Cell Biology, Duke University School of Medicine Verified email at duke.edu Cited by 9943 |
Genome-wide analysis of estrogen receptor binding sites
The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and
the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA …
the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA …
[HTML][HTML] Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
The evolution of prostate cancer from an androgen-dependent state to one that is androgen-independent
marks its lethal progression. The androgen receptor (AR) is essential in both, …
marks its lethal progression. The androgen receptor (AR) is essential in both, …
[HTML][HTML] FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription
Complex organisms require tissue-specific transcriptional programs, yet little is known about
how these are established. The transcription factor FoxA1 is thought to contribute to gene …
how these are established. The transcription factor FoxA1 is thought to contribute to gene …
Shaping chromatin states in prostate cancer by pioneer transcription factors
The androgen receptor (AR) is a critical therapeutic target in prostate cancer that responds
to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the …
to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the …
[PDF][PDF] A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth
Androgen receptor (AR) is a ligand-dependent transcription factor that plays a key role in
prostate cancer. Little is known about the nature of AR cis-regulatory sites in the human …
prostate cancer. Little is known about the nature of AR cis-regulatory sites in the human …
[PDF][PDF] Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking
Androgen receptor (AR) plays a critical role in the development and progression of prostate
cancer, where it is a key therapeutic target. Here we report that, in contrast to estrogen …
cancer, where it is a key therapeutic target. Here we report that, in contrast to estrogen …
Nucleosome dynamics define transcriptional enhancers
Chromatin plays a central role in eukaryotic gene regulation. We performed genome-wide
mapping of epigenetically marked nucleosomes to determine their position both near …
mapping of epigenetically marked nucleosomes to determine their position both near …
Histone modifications and chromatin organization in prostate cancer
Epigenetic mechanisms, including histone modifications, nucleosomal remodeling and
chromosomal looping, contribute to the onset and progression of prostate cancer. Recent …
chromosomal looping, contribute to the onset and progression of prostate cancer. Recent …
[HTML][HTML] Alternative polyadenylation of mRNA and its role in cancer
Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3′
end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from …
end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from …
Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes
Tumor suppressors are mostly defined by inactivating mutations in tumors, yet little is known
about their epigenetic features in normal cells. Through integrative analysis of 1,134 …
about their epigenetic features in normal cells. Through integrative analysis of 1,134 …