The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public
health. The virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme …

By lacking de novo purine biosynthesis enzymes, Plasmodium falciparum requires purine
nucleoside uptake from host cells. The indispensable nucleoside transporter ENT1 of P. …

As a critical sphingolipid metabolite, sphingosine-1-phosphate (S1P) plays an essential role
in immune and vascular systems. There are five S1P receptors, designated as S1PR1 to …

Dear Editor, Pannexin 1 (PANX1) plays extensive physiological roles across diverse fields
of biology, including cell death, 1, 2 inflammation, 3 cancer progression, 4 and neurological …

3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHPS) is a key enzyme in the
shikimate pathway for the biosynthesis of aromatic compounds. L -Phe and L -Tyr bind to the …

Steroid hormones are essential in stress response, immune system regulation, and reproduction
in mammals. Steroids with 3-oxo-Δ 4 structure, such as testosterone or progesterone, …

Plasmodium falciparum, the deadliest causal agent of malaria, caused more than half of the
229 million malaria cases worldwide in 2019. The emergence and spreading of frontline …

Concentrative nucleoside transporters (CNTs), members of the solute carrier (SLC) 28
transporter family, facilitate the salvage of nucleosides and therapeutic nucleoside derivatives …

Acetate is found ubiquitously in the natural environment and can be used as an exogenous
carbon source by bacteria, fungi, and mammalian cells. A representative member of the …

The subcortical maternal complex (SCMC) plays a crucial role in early embryonic development.
Malfunction of SCMC leads to reproductive diseases in women. However, the molecular …