The neuroanatomical architecture is considered to be the basis for understanding brain
function and dysfunction. However, existing imaging tools have limitations for brainwide …

The precise annotation and accurate identification of neural structures are prerequisites for
studying mammalian brain function. The orientation of neurons and neural circuits is usually …

Tissue optical clearing technique provides a prospective solution for the application of
advanced optical methods in life sciences. This paper gives a review of recent developments in …

Targeted delivery of a nanovaccine loaded with a tumor antigen and adjuvant to the lymph
nodes (LNs) is an attractive approach for improving cancer immunotherapy outcomes. …

Release of ATP from astrocytes is required for Ca 2+ wave propagation among astrocytes 1
, 2 , 3 and for feedback modulation of synaptic functions 2 , 4 , 5 . However, the mechanism …

Even as the study of plant genomics rapidly develops through the use of high-throughput
sequencing techniques, traditional plant phenotyping lags far behind. Here we develop a high-…

Dendritic and axonal morphology reflects the input and output of neurons and is a defining
feature of neuronal types 1 , 2 , yet our knowledge of its diversity remains limited. Here, to …

An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …

Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain
activity. However, the whole-brain organization of PFC axon projections remains poorly …

A two-dimensional map of blood flow is crucial for physiological studies. We present a
modified laser speckle imaging method (LSI) that is based on the temporal statistics of a time-…