Mutation or disruption of the SH3 and ankyrin repeat domains 3 (SHANK3) gene represents
a highly penetrant, monogenic risk factor for autism spectrum disorder, and is a cause of …

Background Despite the high cure rate of T cell acute lymphoblastic leukemia (T-ALL), drug
resistance to chemotherapy remains a significant clinical problem. Bone marrow …

Aging in humans is intricately linked with alterations in circadian rhythms concomitant with
physiological decline and stem cell exhaustion. However, whether the circadian machinery …

Pericytes play essential roles in blood–brain barrier (BBB) integrity and dysfunction or
degeneration of pericytes is implicated in a set of neurological disorders although the underlying …

Abnormal cancer antioxidant capacity is considered as a potential mechanism of tumor
malignancy. Modulation of oxidative stress status is emerging as an anti-cancer treatment. Our …

Although somatic cells can be successfully programmed to create pluripotent stem cells by
ectopically expressing defined transcriptional factors, reprogramming efficiency is low and the …

The generation of human induced pluripotent stem cells (hiPSCs) opens a prospect for
regenerative medicine. However, transplantation of somatic cells derived from hiPSCs still harbor …

Emerging evidence has revealed that Nestin not only serves as a biomarker for multipotent
stem cells, but also regulates cell proliferation and invasion in various tumors. However, the …

Gene editing in non-human primates may lead to valuable models for exploring the
etiologies and therapeutic strategies of genetically based neurological disorders in humans. …

Background Gut microbiota colonization is critical for immune education and nutrient metabolism.
Research shows that melatonin has beneficial effects as a therapy for many diseases …