Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause
of ageing is the accumulation of epigenetic noise that disrupts gene expression patterns, …

Nuclear factor-κB (NF-κB) is an important transcription factor that induces the expression of
antiviral genes and viral genes. NF-κB activation needs the activation of NF-κB upstream …

Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …

Single-cell analyses parse the brain’s billions of neurons into thousands of ‘cell-type’ clusters
residing in different brain structures 1 . Many cell types mediate their functions through …

Ageing is a degenerative process leading to tissue dysfunction and death. A proposed cause
of ageing is the accumulation of epigenetic noise, which disrupts youthful gene expression …

Delineating the gene regulatory programs underlying complex cell types is fundamental for
understanding brain functions in health and disease. Here, we comprehensively examine …

Duck hepatitis A virus type 1 (DHAV-1) is one of the most common and lethal pathogens in
young ducklings. Live-attenuated DHAV vaccine (CH60 strain) developed by passaging in …

Duck hepatitis A virus 1 (DHAV-1) belongs to the genus Avihepatovirus in the family
Picornaviridae. Little research has been carried out on the non-structural proteins of this virus. This …

To investigate the function of the duck enteritis virus (DEV) tegument protein US10, we
generated US10 deletion and revertant mutants (ΔUS10 and US10FRT) via two-step RED …