Disentangling the relative response sensitivity of soil autotrophic (R a ) and heterotrophic
respiration (R h ) to nitrogen (N) enrichment is pivotal for evaluating soil carbon (C) storage …

10.7554/eLife.29702.001 Over 80% of multiple-tested siRNAs and shRNAs targeting CD95
or CD95 ligand (CD95L) induce a form of cell death characterized by simultaneous …

Trinucleotide repeat ( TNR ) expansions in the genome cause a number of degenerative
diseases. A prominent TNR expansion involves the triplet CAG in the huntingtin ( HTT ) gene …

Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions
2–7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer …

10.7554/eLife.17589.001 Skeletal muscle is highly sensitive to mutations in genes that
participate in membrane stability and cellular attachment, which often leads to muscular dystrophy…

Latent TGFβ binding proteins (LTBPs) regulate the extracellular availability of latent TGFβ.
LTBP4 was identified as a genetic modifier of muscular dystrophy in mice and humans. An in-…

10.7554/eLife.38621.001 CD95/Fas ligand binds to the death receptor CD95 to induce
apoptosis in sensitive cells. We previously reported that CD95L mRNA is enriched in sequences …

Disruption of the dystrophin complex causes muscle injury, dysfunction, cell death and
fibrosis. Excess transforming growth factor (TGF) β signaling has been described in human …

Exon skipping uses antisense oligonucleotides as a treatment for genetic diseases. The
antisense oligonucleotides used for exon skipping are designed to bypass premature stop …

Off-target effects (OTEs) represent a significant caveat for RNAi caused by substantial
complementarity between siRNAs and unintended mRNAs. We now discuss the existence of three …