Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

Background Vitamin D is crucial for maintenance of musculoskeletal health, and might also
have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D …

Context Clopidogrel therapy improves cardiovascular outcomes in patients with acute coronary
syndromes and following percutaneous coronary intervention by inhibiting adenosine …

Background— C-reactive protein (CRP) is a heritable marker of chronic inflammation that is
strongly associated with cardiovascular disease. We sought to identify genetic variants that …

Platelets are the second most abundant cell type in blood and are essential for maintaining
haemostasis. Their count and volume are tightly controlled within narrow physiological …

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment,
growth retardation and impaired physical capacity. To understand further the genetic factors …

To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe …

Methods We genotyped a functional variant in CES1, G143E, in participants of the
Pharmacogenomics of Anti-Platelet Intervention (PAPI) study (n= 566) and in 350 patients with …

Height is a classic complex trait with common variants in a growing list of genes known to
contribute to the phenotype. Using a genecentric genotyping array targeted toward …

Background— Aspirin or dual antiplatelet therapy with aspirin and clopidogrel is a standard
therapy for patients who are at increased risk for cardiovascular events. However, the …