Importance Polygenic risk scores comprising millions of single-nucleotide polymorphisms (SNPs)
could be useful for population-wide coronary heart disease (CHD) screening. …

Importance Large-scale DNA sequencing identifies incidental rare variants in established
Mendelian disease genes, but the frequency of related clinical phenotypes in unselected …

Genetic association studies often examine features independently, potentially missing
subpopulations with multiple phenotypes that share a single cause. We describe an approach that …

Current approaches to predicting a cardiovascular disease (CVD) event rely on conventional
risk factors and cross-sectional data. In this study, we applied machine learning and deep …

Endothelial-to-mesenchymal transition (EndoMT) is a cellular process often initiated by the
transforming growth factor β (TGF-β) family of ligands. Although required for normal heart …

Background : Pulmonary hypertension (PH) is a common and morbid complication of left
heart disease with 2 subtypes: isolated post-capillary pulmonary hypertension (Ipc-PH) and …

A postacute COVID-19 multisystem inflammatory syndrome (MIS) has been recognized as a
rare, yet severe, complication of SARS-CoV-2 infection. First characterized in children, 1, 2 …

Purpose Assessing the risk of common, complex diseases requires consideration of clinical
risk factors as well as monogenic and polygenic risks, which in turn may be reflected in …

Background: The mechanism of adverse limb events associated with peripheral artery
disease remains incompletely understood. We investigated whether microvascular disease is …

Importance Pulmonary hypertension (PH) is diagnosed by a mean pulmonary arterial
pressure (mPAP) value of at least 25 mm Hg during right heart catheterization (RHC). While …