Epithelial to mesenchymal transition (EMT) is a dynamic cellular process that is essential for
the development of metastatic disease. During EMT, a tumor cell with epithelial …

Objectives Recurrent respiratory papillomatosis (RRP) is a chronic disease of the respiratory
tract that occurs in both children and adults. It is caused by the human papillomavirus (HPV)…

Nanog is a transcription factor that is well‐established as a key regulator of embryonic stem
cell (ESC) maintenance. Recent evidence demonstrates that Nanog is dysregulated and …

Copper plays an essential role in promoting angiogenesis. Tumors that become angiogenic
acquire the ability to enter a phase of rapid growth and exhibit increased metastatic potential…

Purpose: Tetrathiomolybdate (TM), a copper-lowering agent, has been shown in preclinical
murine tumor models to be antiangiogenic. We evaluated the antitumor activity of TM in …

BACKGROUND The survival of patients with head and neck squamous cell carcinoma (HNSCC)
remains unaffected despite recent therapeutic advances. To reverse this trend, reliable …

Tumor metastasis is the major cause of morbidity and mortality in patients with breast cancer.
It is critical to identify metastasis enabling genes and understand how they are responsible …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent cancer
worldwide with about 600,000 new cases diagnosed in the last year. Our laboratory showed that …

Members of the protein kinase C (PKC) family have long been studied for their contributions
to oncogenesis. Among the ten different isoforms of this family of serine/threonine kinases, …

Tetrathiomolybdate (TM), a specific copper chelator, has been shown to be a potent
antiangiogenic and antimetastatic compound possibly through suppression of the NFκB signaling …