Single-cell transcriptomic technologies have emerged as powerful tools to explore cellular
heterogeneity at the resolution of individual cells. Previous scientific knowledge in cell biology …

Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to
subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been …

Women with germline BRCA1 mutations (BRCA1 +/mut ) have increased risk for hereditary
breast cancer. Cancer initiation in BRCA1 +/mut is associated with premalignant changes in …

Targeting synthetic lethal interactions is a promising new therapeutic approach to exploit
specific changes that occur within cancer cells. Multiple approaches to investigate these …

Breast cancer brain metastasis (BCBM) is a lethal disease with no effective treatments. Prior
work has shown that brain cancers and metastases are densely infiltrated with anti-…

Around 95% of anti-cancer drugs that show promise during preclinical study fail to gain FDA-approval
for clinical use. This failure of the preclinical pipeline highlights the need for …

Tissues are complex mixtures of different cell subtypes, and this diversity is increasingly
characterized using high-throughput single cell analysis methods. However, these efforts are …

The mammary epithelial cell (MEC) system is a bilayered ductal epithelium of luminal and
basal cells, maintained by a lineage of stem and progenitor populations. Here, we used …

The adult human breast is comprised of an intricate network of epithelial ducts and lobules
that are embedded in connective and adipose tissue 1 , 2 – 3 . Although most previous …

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with steadily
increasing incidence and poor prognosis. Despite recent success with immunotherapy, 50…