In embryonic stem cells ( ESC s), gene regulatory networks ( GRN s) coordinate gene
expression to maintain ESC identity; however, the complete repertoire of factors regulating the …

Formation and resolution of multicellular rosettes can drive convergent extension (CE) type
cell rearrangements during tissue morphogenesis. Rosette dynamics are regulated by both …

We present a stochastic programming framework for finding the optimal vaccination policy
for controlling infectious disease epidemics under parameter uncertainty. Stochastic …

We present a new method for solving stochastic programs with joint chance constraints with
random technology matrices and discretely distributed random data. The problem can be …

T cell receptor (TCR) induces a series of signaling cascades and leads to activation of
multiple transcription factors, including NF-κB. Although the mechanism of TCR-induced NF-κB …

We show that the robustness of an inverse relationship between the real interest rate and real
oil price depends crucially on how the real interest rate is calculated, and the time-frame of …

The androgen receptor (AR) is expressed in a subset of prostate stromal cells and functional
stromal cell AR is required for normal prostate developmental and influences the growth of …

Myotonic dystrophy type 1 (DM1) is an inherited disease characterized by the inability to relax
contracted muscles. Affected individuals carry large CTG expansions that are toxic when …

Purpose : Hedgehog signaling regulates Gli transcription factors. Aberrant hedgehog signaling
can be oncogenic and drugs that block hedgehog are being tested as anticancer agents. …

Background Myotonic dystrophy type 1 results from an RNA gain-of-function mutation, in
which DM1 protein kinase (DMPK) transcripts carrying expanded trinucleotide repeats exert …