Richard Parmentier takes up Ferdinand de Saussure's challenge to study the" life of signs in
society" by using semiotic tools proposed by Charles Sanders Peirce. He studies how …

The hypothesis that histaminergic neurons are involved in brain arousal is supported by many
studies. However, the effects of the selective long-term abolition of histaminergic neurons …

… clearly from the semiotic point of view underlying Parmentier's study, that is, from the point of
… system that makes all this possible is what Parmentier presents in this volume. He carefully …

The health of the ocean, central to human well-being, has now reached a critical point. Most
fish stocks are overexploited, climate change and increased dissolved carbon dioxide are …

Histamine H 3 receptor inverse agonists are known to enhance the activity of histaminergic
neurons in brain and thereby promote vigilance and cognition. 1-{3-[3-(4-Chlorophenyl)…

Narcolepsy is characterized by excessive daytime sleepiness (EDS), cataplexy, direct onsets
of rapid eye movement (REM) sleep from wakefulness (DREMs) and deficiency of orexins, …

To determine the respective role played by orexin/hypocretin and histamine (HA) neurons in
maintaining wakefulness (W), we characterized the behavioral and sleep–wake phenotypes …

… An important corollary question is whether H 3 R-agonists induce or … 3 R-antagonists could
be reversed by H 3 R-agonists. To this aim, the effects of imetit (a potent and selective H 3 R-…

… PARMENTIER All my notions are too narrow. Instead of "Sign… But, as Parmentier documents
in this chapter, Peirce recognized … Parmentier second, more specific level as well. Mediation, …

… In the absence of constitutive activity (no R * ), the ligand would act as an agonist by changing
R into LR * . In the presence of a significant amount of R * , the ligand would decrease the …