The correct spatial expression of two Drosophila bithorax complex (BX-C) genes, abdominal-A
(abdA) and Abdominal-B (AbdB), is dependent on the 100-kb intergenic infraabdominal (…

Transient neonatal diabetes mellitus (TNDM) is associated with intra-uterine growth
retardation, dehydration and a lack of insulin. Some TNDM patients exhibit paternal uniparental …

Methylation of CpG dinucleotides is correlated with transcriptional repression of genes, including
imprinted genes. In the case of the imprinted H19 gene, a 2 kb imprinting control region …

In honey bees (Apis mellifera), the epigenetic mark of DNA methylation is central to the
developmental regulation of caste differentiation, but may also be involved in additional …

… The 13 th ranked NV12600-RA is the only gene to deviate from this pattern, showing …
Additionally, in a number of the most frequently methylated genes (including NV12600-RA), there …

Cis-regulatory modules are non-protein-coding regions of DNA essential for the control of
gene expression. One class of regulatory modules is embryonic enhancers, which drive gene …

The H19 imprinted gene is silenced when paternally inherited and active only when inherited
maternally. This is thought to involve a cis-acting control region upstream of H19 that is …

… The number of methylated cytosines in each sample was calculated as in Drewell et al. [33].
At each cytosine site, we compared the number of bisulfite-converted reads (unmethylated) …

A key question in our understanding of the cis-regulation of gene expression during
embryonic development has been the molecular mechanism that directs enhancers to specific …

The extensive infraabdominal (iab) region contains a number of cis-regulatory elements,
including enhancers, silencers, and insulators responsible for directing the developmental …