Unraveling the time domains of corticosteroid hormone influences on brain activity: rapid, slow, and chronic modes
Brain cells are continuously exposed to corticosteroid hormones, although the levels vary (eg,
after stress). Corticosteroids alter neural activity via two receptor types, mineralocorticoid (…
after stress). Corticosteroids alter neural activity via two receptor types, mineralocorticoid (…
Glucocorticoid ultradian rhythmicity directs cyclical gene pulsing of the clock gene period 1 in rat hippocampus
…, RA Sarabdjitsingh… - Journal of …, 2010 - Wiley Online Library
In vivo glucocorticoid (GC) secretion exhibits a distinctive ultradian rhythmicity. The
lipophilic hormone can rapidly diffuse into cells, although only the pulse peak is of sufficient …
lipophilic hormone can rapidly diffuse into cells, although only the pulse peak is of sufficient …
The stressed brain of humans and rodents
After stress, the brain is exposed to waves of stress mediators, including corticosterone (in
rodents) and cortisol (in humans). Corticosteroid hormones affect neuronal physiology in two …
rodents) and cortisol (in humans). Corticosteroid hormones affect neuronal physiology in two …
[PDF][PDF] Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5
Responding to different dynamic levels of stress is critical for mammalian survival. Disruption
of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed …
of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed …
Stress responsiveness varies over the ultradian glucocorticoid cycle in a brain-region-specific manner
RA Sarabdjitsingh, BL Conway-Campbell… - …, 2010 - academic.oup.com
Glucocorticoid hormones are released in rapid hourly hormone bursts by the adrenal gland.
These ultradian oscillations are fundamental to hypothalamic-pituitary-adrenal activity and …
These ultradian oscillations are fundamental to hypothalamic-pituitary-adrenal activity and …
The behavioral phenotype of early life adversity: A 3-level meta-analysis of rodent studies
…, R Van Der Veen, M Joëls, RA Sarabdjitsingh - Neuroscience & …, 2019 - Elsevier
Altered cognitive performance is considered an intermediate phenotype mediating early life
adversity (ELA) effects on later-life development of mental disorders, eg depression. …
adversity (ELA) effects on later-life development of mental disorders, eg depression. …
Disrupted corticosterone pulsatile patterns attenuate responsiveness to glucocorticoid signaling in rat brain
RA Sarabdjitsingh, S Isenia, A Polman… - …, 2010 - academic.oup.com
Chronically elevated circulating glucocorticoid levels are although to enhance vulnerability
to psychopathology. Here we hypothesized that such sustained glucocorticoid levels, …
to psychopathology. Here we hypothesized that such sustained glucocorticoid levels, …
Increasing the statistical power of animal experiments with historical control data
…, RA Sarabdjitsingh… - Nature …, 2021 - nature.com
Low statistical power reduces the reliability of animal research; yet, increasing sample sizes
to increase statistical power is problematic for both ethical and practical reasons. We …
to increase statistical power is problematic for both ethical and practical reasons. We …
[HTML][HTML] Effects of early life stress on synaptic plasticity in the developing hippocampus of male and female rats
…, CC Hoogenraad, M Joels, RA Sarabdjitsingh - PloS one, 2016 - journals.plos.org
Introduction Early life stress (ELS) increases the risk for developing psychopathology in
adulthood. When these effects occur is largely unknown. We here studied at which time during …
adulthood. When these effects occur is largely unknown. We here studied at which time during …
Ultradian corticosterone pulses balance glutamatergic transmission and synaptic plasticity
RA Sarabdjitsingh, J Jezequel… - Proceedings of the …, 2014 - National Acad Sciences
The rodent adrenal hormone corticosterone (CORT) reaches the brain in hourly ultradian
pulses, with a steep rise in amplitude before awakening. The impact of a single CORT pulse on …
pulses, with a steep rise in amplitude before awakening. The impact of a single CORT pulse on …