To identify novel genes associated with ALS, we undertook two lines of investigation. We
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls…

Increasingly, repeat expansions are being identified as part of the complex genetic
architecture of amyotrophic lateral sclerosis. To date, several repeat expansions have been …

Background Amyotrophic lateral sclerosis (ALS) is considered to be caused by both genetic
and environmental factors. The causal cascade is, however, not known. We aimed to assess …

… Dekker a 1 , Joke JFA van Vugt a , Rick A. van der Spek a , Henk-Jan Westeneng a ,
Lindy JBG Kool a , Kevin P. Kenna a , Wouter van Rheenen a , Sara L. Pulit a , Russell L. …

Background Rolandic epilepsy (RE) is the most common genetic childhood epilepsy, consisting
of focal, nocturnal seizures and frequent neurodevelopmental impairments in speech, …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects 1 in ~350
individuals. Genetic association studies have established ALS as a multifactorial disease …

T-cell-restricted intracellular antigen-1 (TIA1) has been recently reported as a novel
amyotrophic lateral sclerosis (ALS) related gene, and has already been adopted in a resource …

Background: An inadequate body temperature in preterm infants influences morbidity and
mortality. Continuous rectal measurement is a reliable method to measure body temperature …

… Quality assessment was undertaken independently by 2 authors (Van Noort-van der Spek
and Franken) by using the Newcastle-Ottawa Scale. This scale assesses the quality of case-…

Thyroid hormones (TH) are crucial for growth and development and play an important role in
energy homeostasis. Although serum TH levels are relatively constant in the physiological …