Higher order chromatin structure presents a barrier to the recognition and repair of DNA
damage. Double-strand breaks (DSBs) induce histone H2AX phosphorylation, which is …

The Spo11 protein initiates meiotic recombination by generating DNA double-strand breaks
(DSBs) and is required for meiotic synapsis in S. cerevisiae. Surprisingly, Spo11 homologs …

Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular
responses to ionizing radiation (IR), including the initiation of cell cycle checkpoints 1 . Histone …

… ence in the relative frequencies of spermatocyte subnificantly different from 1; Student’st
test) (… Some degree of XY asynapsis age expression level for autosomal genes (Student’st …

Genetic recombination occurs during meiosis, the key developmental programme of
gametogenesis. Recombination in mammals has been recently linked to the activity of a histone H3 …

Meiotic recombination predominantly occurs at discrete genomic loci called recombination
hotspots, but the features defining these areas are still largely unknown (reviewed in refs 1 ). …

A key step in homologous recombination is the alignment and pairing of homologous DNAs.
The Escherichia coli RecA protein initiates pairing by binding to single-strand DNA, forming …

Sex chromosomes are subject to sex-specific selective evolutionary forces 1 , 2 . One model
predicts that genes with sex-biased expression should be enriched on the X chromosome 2 …

Introduction The dramatic events of meiotic recombination culminate in the exchange of
genetic information between parental chromosomes and ensure the production of genetically …

Changes in gene expression after treatment of Escherichia coli cultures with mitomycin C
were assessed using gene array technology. Unexpectedly, a large number of genes (nearly …