User profiles for R. E. Toes
 | rene toesVerified email at lumc.nl Cited by 60876 |
Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens
…, R Thomas, J Rossjohn, RE Toes - Nature Reviews …, 2015 - nature.com
… Finally, the ways in which these novel insights are being exploited therapeutically to re-…
Finally, we describe ways in which these novel insights could be exploited therapeutically to re-…
Finally, we describe ways in which these novel insights could be exploited therapeutically to re-…
A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis
Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1
locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-…
locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-…
Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.
RE Toes, R Offringa, RJ Blom… - Proceedings of the …, 1996 - National Acad Sciences
Vaccination with synthetic peptides representing cytotoxic T lymphocyte (CTL) epitopes can
lead to a protective CTL-mediated immunity against tumors or viruses. We now report that …
lead to a protective CTL-mediated immunity against tumors or viruses. We now report that …
Anti–cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways
…, MR Daha, TWJ Huizinga, RE Toes - … : Official Journal of …, 2009 - Wiley Online Library
Objective It has been suggested that anti–citrullinated protein antibodies (ACPAs) play an
important role in the pathogenesis of rheumatoid arthritis (RA). To exert their pathologic effects…
important role in the pathogenesis of rheumatoid arthritis (RA). To exert their pathologic effects…
Enhanced tumor outgrowth after peptide vaccination. Functional deletion of tumor-specific CTL induced by peptide vaccination can lead to the inability to reject tumors.
CTL can play an important role in the defense against tumors. Protective CTL-mediated
immunity can be established in animal tumor models after vaccination with synthetic peptides …
immunity can be established in animal tumor models after vaccination with synthetic peptides …
Possibilities for preventive treatment in rheumatoid arthritis? Lessons from experimental animal models of arthritis: a systematic literature review and meta-analysis
Objective Current research in rheumatoid arthritis focuses on preclinical disease phases as
it is hypothesised that early preclinical treatment might prevent progression to full-blown …
it is hypothesised that early preclinical treatment might prevent progression to full-blown …
High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation
…, JM Vossen, AC Lankester, RE Toes… - Clinical infectious …, 2002 - academic.oup.com
An increase in the incidence of adenovirus (AdV) infection leading to death among children
who have undergone allogeneic stem-cell transplantation has made it necessary to find new …
who have undergone allogeneic stem-cell transplantation has made it necessary to find new …
Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the 'AMC-Senshu'method
… However, our study suggests that the extent and nature of citrullination and carbamylation
in the joint should be re-evaluated especially in light of our recently described anti-CarP …
in the joint should be re-evaluated especially in light of our recently described anti-CarP …
[HTML][HTML] Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis
The HLA locus is the strongest risk factor for anti-citrullinated protein antibody (ACPA) +
rheumatoid arthritis (RA). Despite considerable efforts in the last 35 years, this association is …
rheumatoid arthritis (RA). Despite considerable efforts in the last 35 years, this association is …
HLA and rheumatoid arthritis: how do they connect?
…, D van der Woude, TW Huizinga, RE Toes - Annals of …, 2014 - Taylor & Francis
Rheumatoid arthritis (RA) is a destructive autoimmune disease that mainly affects synovial
joints. RA patients can be subdivided in two distinct disease subsets based on the presence …
joints. RA patients can be subdivided in two distinct disease subsets based on the presence …