User profiles for R. H. Houtkooper
Riekelt HoutkooperProfessor of Translational Metabolism, Academic Medical Center (AMC), Amsterdam Verified email at amc.nl Cited by 21266 |
Sirtuins as regulators of metabolism and healthspan
RH Houtkooper, E Pirinen, J Auwerx - Nature reviews Molecular cell …, 2012 - nature.com
Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1–SIRT7)
has received much attention for its regulatory role, mainly in metabolism and ageing. …
has received much attention for its regulatory role, mainly in metabolism and ageing. …
[PDF][PDF] Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
S Timmers, E Konings, L Bilet, RH Houtkooper… - Cell metabolism, 2011 - cell.com
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function
and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we …
and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we …
[HTML][HTML] The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
C Cantó, RH Houtkooper, E Pirinen, DY Youn… - Cell metabolism, 2012 - cell.com
As NAD + is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as
a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line …
a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line …
[HTML][HTML] The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
L Mouchiroud, RH Houtkooper, N Moullan, E Katsyuba… - Cell, 2013 - cell.com
NAD + is an important cofactor regulating metabolic homeostasis and a rate-limiting
substrate for sirtuin deacylases. We show that NAD + levels are reduced in aged mice and …
substrate for sirtuin deacylases. We show that NAD + levels are reduced in aged mice and …
Mitonuclear protein imbalance as a conserved longevity mechanism
Longevity is regulated by a network of closely linked metabolic systems. We used a
combination of mouse population genetics and RNA interference in Caenorhabditis elegans to …
combination of mouse population genetics and RNA interference in Caenorhabditis elegans to …
The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
RH Houtkooper, C Cantó, RJ Wanders… - Endocrine …, 2010 - academic.oup.com
A century after the identification of a coenzymatic activity for NAD + , NAD + metabolism has
come into the spotlight again due to the potential therapeutic relevance of a set of enzymes …
come into the spotlight again due to the potential therapeutic relevance of a set of enzymes …
[PDF][PDF] PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
…, H Yamamoto, A Huber, B Kiss, RH Houtkooper… - Cell metabolism, 2011 - cell.com
SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a
number of enzymes and transcriptional regulators. The fact that NAD + levels control SIRT1 …
number of enzymes and transcriptional regulators. The fact that NAD + levels control SIRT1 …
Cardiolipin, the heart of mitochondrial metabolism
RH Houtkooper, FM Vaz - Cellular and Molecular Life Sciences, 2008 - Springer
Cardiolipin is a unique phospholipid, which is almost exclusively localized in the
mitochondrial inner membrane where it is synthesized from phosphatidylglycerol and …
mitochondrial inner membrane where it is synthesized from phosphatidylglycerol and …
[HTML][HTML] The metabolic footprint of aging in mice
RH Houtkooper, C Argmann, SM Houten, C Cantó… - Scientific reports, 2011 - nature.com
Aging is characterized by a general decline in cellular function, which ultimately will affect
whole body homeostasis. Although DNA damage and oxidative stress all contribute to aging, …
whole body homeostasis. Although DNA damage and oxidative stress all contribute to aging, …
Metabolic flexibility as an adaptation to energy resources and requirements in health and disease
…, MR Soeters, RCI Wüst, RH Houtkooper - Endocrine …, 2018 - academic.oup.com
The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In this …
utilization, dependent on availability and requirement, is known as metabolic flexibility. In this …