User profiles for R. H. Houtkooper

Riekelt Houtkooper

Professor of Translational Metabolism, Academic Medical Center (AMC), Amsterdam
Verified email at amc.nl
Cited by 21266

Sirtuins as regulators of metabolism and healthspan

RH Houtkooper, E Pirinen, J Auwerx - Nature reviews Molecular cell …, 2012 - nature.com
Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1–SIRT7)
has received much attention for its regulatory role, mainly in metabolism and ageing. …

[PDF][PDF] Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans

S Timmers, E Konings, L Bilet, RH Houtkooper… - Cell metabolism, 2011 - cell.com
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function
and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we …

[HTML][HTML] The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

C Cantó, RH Houtkooper, E Pirinen, DY Youn… - Cell metabolism, 2012 - cell.com
As NAD + is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as
a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line …

[HTML][HTML] The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling

L Mouchiroud, RH Houtkooper, N Moullan, E Katsyuba… - Cell, 2013 - cell.com
NAD + is an important cofactor regulating metabolic homeostasis and a rate-limiting
substrate for sirtuin deacylases. We show that NAD + levels are reduced in aged mice and …

Mitonuclear protein imbalance as a conserved longevity mechanism

RH Houtkooper, L Mouchiroud, D Ryu, N Moullan… - Nature, 2013 - nature.com
Longevity is regulated by a network of closely linked metabolic systems. We used a
combination of mouse population genetics and RNA interference in Caenorhabditis elegans to …

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

RH Houtkooper, C Cantó, RJ Wanders… - Endocrine …, 2010 - academic.oup.com
A century after the identification of a coenzymatic activity for NAD + , NAD + metabolism has
come into the spotlight again due to the potential therapeutic relevance of a set of enzymes …

[PDF][PDF] PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

…, H Yamamoto, A Huber, B Kiss, RH Houtkooper… - Cell metabolism, 2011 - cell.com
SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a
number of enzymes and transcriptional regulators. The fact that NAD + levels control SIRT1 …

Cardiolipin, the heart of mitochondrial metabolism

RH Houtkooper, FM Vaz - Cellular and Molecular Life Sciences, 2008 - Springer
Cardiolipin is a unique phospholipid, which is almost exclusively localized in the
mitochondrial inner membrane where it is synthesized from phosphatidylglycerol and …

[HTML][HTML] The metabolic footprint of aging in mice

RH Houtkooper, C Argmann, SM Houten, C Cantó… - Scientific reports, 2011 - nature.com
Aging is characterized by a general decline in cellular function, which ultimately will affect
whole body homeostasis. Although DNA damage and oxidative stress all contribute to aging, …

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

…, MR Soeters, RCI Wüst, RH Houtkooper - Endocrine …, 2018 - academic.oup.com
The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In this …