User profiles for R. J. Challis

Richard J Challis

Wellcome Sanger Institute
Verified email at sanger.ac.uk
Cited by 3412

[HTML][HTML] Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled …

…, M Carr, MW Carroll, V Carter, K Cathie, RJ Challis… - The Lancet, 2020 - thelancet.com
Background The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
might be curtailed by vaccination. We assessed the safety, reactogenicity, and …

Genomic islands of speciation separate cichlid ecomorphs in an East African crater lake

M Malinsky, RJ Challis, AM Tyers, S Schiffels, Y Terai… - Science, 2015 - science.org
The genomic causes and effects of divergent ecological selection during speciation are still
poorly understood. Here we report the discovery and detailed characterization of early-stage …

[HTML][HTML] Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia

HM Kyriacou, GN Stone, RJ Challis, A Raza… - Molecular and …, 2006 - Elsevier
The Plasmodium falciparum variant erythrocyte surface antigens known as PfEMP1, encoded
by the var gene family, are thought to play a crucial role in malaria pathogenesis because …

A Role for MORE AXILLARY GROWTH1 (MAX1) in Evolutionary Diversity in Strigolactone Signaling Upstream of MAX2

RJ Challis, J Hepworth, C Mouchel, R Waites… - Plant …, 2013 - academic.oup.com
Strigolactones ( SLs ) are carotenoid-derived phytohormones with diverse roles. They are
secreted from roots as attractants for arbuscular mycorrhizal fungi and have a wide range of …

Phylogeny and DNA barcoding of inquiline oak gallwasps (Hymenoptera: Cynipidae) of the Western Palaearctic

Z Ács, RJ Challis, P Bihari, M Blaxter, A Hayward… - Molecular Phylogenetics …, 2010 - Elsevier
We examine phylogenetic relationships within the Synergus complex of herbivorous inquiline
gallwasps (Hymenoptera; Cynipidae; Synergini) associated with cynipid host galls on oak, …

Mitochondrial barcodes are diagnostic of shared refugia but not species in hybridizing oak gallwasps

JA Nicholls, RJ Challis, S Mutun… - Molecular ecology, 2012 - Wiley Online Library
Mitochondrial DNA barcodes provide a simple taxonomic tool for systematic and ecological
research, with particular benefit for poorly studied or species‐rich taxa. Barcoding assumes …

A high-coverage draft genome of the mycalesine butterfly Bicyclus anynana

…, H Connahs, ML Aslam, S Kumar, RJ Challis… - …, 2017 - academic.oup.com
The mycalesine butterfly Bicyclus anynana, the “Squinting bush brown,” is a model organism
in the study of lepidopteran ecology, development, and evolution. Here, we present a draft …

The phylogeographical clade trade: tracing the impact of human‐mediated dispersal on the colonization of northern Europe by the oak gallwasp Andricus kollari

GN Stone, RJ Challis, RJ Atkinson, G Csóka… - Molecular …, 2007 - Wiley Online Library
… Graham Stone and Richard Challis contributed equally to this manuscript. … Richard Challis,
Alex Hayward and Sonja Preuss apply molecular phylogenetic approaches to a wide range …

Field cricket genome reveals the footprint of recent, abrupt adaptation in the wild

…, X Zhang, M Blaxter, T Cezard, RJ Challis… - Evolution …, 2020 - academic.oup.com
… An index page links to an Ensembl page, where assembly statistics can be visualized using
a Challis plot or compared in tabular format. A plot illustrating codon usage is presented, …

Evolution of spider silks: conservation and diversification of the C‐terminus

RJ Challis, SL Goodacre, GM Hewitt - Insect molecular biology, 2006 - Wiley Online Library
Abstract Analysis of DNA sequences coding for the C‐terminus of spider silk proteins from a
range of spiders suggests that many silk C‐termini share a common origin, and that their …