The MHC Class I-related receptor, FcRn, transports antibodies of the immunoglobulin G (IgG)
class within and across a diverse array of different cell types. Through this transport, FcRn …

Estimation of a parameter of interest from image data represents a task that is commonly
carried out in single molecule microscopy data analysis. The determination of the positional …

The neonatal Fc receptor, FcRn, is related to MHC class I with respect to its structure and
association with β 2 microglobulin (β 2 m). However, by contrast with MHC class I molecules, …

One of the most basic questions in single-molecule microscopy concerns the accuracy with
which the location of a single molecule can be determined. Using the Fisher information …

Preclinical tests of therapeutic antibodies are frequently carried out in mice to evaluate
pharmacokinetics and efficacy. However, the observation that mouse IgG are cleared rapidly from …

We have engineered the Fc region of a human immunoglobulin G (IgG) to generate a mutated
antibody that modulates the concentrations of endogenous IgGs in vivo. This has been …

The major histocompatibility complex (MHC) class l-related receptor FcRn is involved in
regulating serum gammaglobulin (IgG) levels in mice. With the aim of increasing the serum half-…

The MHC class I-related receptor, FcRn, plays a central role in regulating the serum levels of
IgG. FcRn is expressed in endothelial cells, suggesting that these cells may be involved in …

The transfer of maternal γ-globulin (IgG) provides the neonate with humoral immunity during
early life. In humans, maternal IgG is transported across the placenta during the third …

IgG transport within and across cells is essential for effective humoral immunity. Through a
combination of biochemical and in vivo analyses, the MHC class I-related neonatal Fc …