Directional migration is an important component of cell motility. Although the basic mechanisms
of random cell movement are well characterized, no single model explains the complex …

Cells migrating on flat two-dimensional (2D) surfaces use actin polymerization to extend the
leading edge of the plasma membrane during lamellipodia-based migration. This mode of …

The importance of cell migration for both normal physiological functions and disease
processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) …

We search in this paper for context-specific modes of three-dimensional (3D) cell migration
using imaging for phosphatidylinositol (3,4,5)-trisphosphate (PIP3) and active Rac1 and …

Cells use actomyosin contractility to move through three-dimensional (3D) extracellular
matrices. Contractility affects the type of protrusions cells use to migrate in 3D, but the …

INTRODUCTION The human body is a crowded place. This crowding is even more acute
when the regulation of cell growth and proliferation fails during the formation of a tumor. …

Size control is fundamental in tissue development and homeostasis 1 , 2 . Although the role
of cell proliferation in these processes has been widely studied, the mechanisms that control …

Aberrant extracellular matrix (ECM) assembly surrounding implanted biomaterials is the
hallmark of the foreign body response, in which implants become encapsulated in thick fibrous …

Cells migrate through 3D environments using a surprisingly wide variety of molecular
mechanisms. These distinct modes of migration often rely on the same intracellular components, …

Cell interactions with the extracellular matrix (ECM) can regulate multiple cellular activities
and the matrix itself in dynamic, bidirectional processes. One such process is local proteolytic …