At the beginning of the twenty-first century, there are 30,000 golf courses and 55 million
people who play golf worldwide. In the USA alone, the value of golf club memberships sold in …

Mitochondria are fundamental for metabolic homeostasis in all multicellular eukaryotes. In
the nervous system, mitochondria-generated adenosine triphosphate (ATP) is required to …

The blood–brain barrier (BBB) remains one of the most significant limitations to treatments
of central nervous system (CNS) disorders including brain tumors, neurodegenerative …

Background Treatment with cetuximab, a monoclonal antibody directed against the epidermal
growth factor receptor, improves overall and progression-free survival and preserves the …

KRAS is the most frequently mutated oncogene in cancer and encodes a key signalling
protein in tumours 1 , 2 . The KRAS(G12C) mutant has a cysteine residue that has been …

Detection of circulating tumor DNA (ctDNA) after resection of stage II colon cancer may
identify patients at the highest risk of recurrence and help inform adjuvant treatment decisions. …

Background No therapies for targeting KRAS mutations in cancer have been approved. The
KRAS p.G12C mutation occurs in 13% of non–small-cell lung cancers (NSCLCs) and in 1 to …

Background—Our aim was to observe ultrasound-induced intravascular microbubble
destruction in vivo and to characterize any resultant bioeffects. Methods and Results—Intravital …

Objectives: To undertake a prospective epidemiological study of the injuries sustained in
English youth academy football over two competitive seasons. Methods: Player injuries were …

Purpose To determine whether adding bevacizumab, with or without mitomycin, to
capecitabine monotherapy improves progression-free survival (PFS) in patients with …