Rapid DNA replication origin licensing protects stem cell pluripotency
JP Matson, R Dumitru, P Coryell, RM Baxley, W Chen… - Elife, 2017 - elifesciences.org
10.7554/eLife.30473.001 Complete and robust human genome duplication requires loading
minichromosome maintenance (MCM) helicase complexes at many DNA replication origins…
minichromosome maintenance (MCM) helicase complexes at many DNA replication origins…
[HTML][HTML] Mechanisms of DNA damage tolerance: Post-translational regulation of PCNA
W Leung, RM Baxley, GL Moldovan, AK Bielinsky - Genes, 2018 - mdpi.com
DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful
duplication of our genomes, mechanisms have evolved to deal with damage encountered …
duplication of our genomes, mechanisms have evolved to deal with damage encountered …
[HTML][HTML] Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy
…, B Isidor, RF Shearer, X Latypova, RM Baxley… - Nature …, 2022 - nature.com
Embryonic development is dictated by tight regulation of DNA replication, cell division and
differentiation. Mutations in DNA repair and replication genes disrupt this equilibrium, giving …
differentiation. Mutations in DNA repair and replication genes disrupt this equilibrium, giving …
[HTML][HTML] Mcm10: a dynamic scaffold at eukaryotic replication forks
RM Baxley, AK Bielinsky - Genes, 2017 - mdpi.com
To complete the duplication of large genomes efficiently, mechanisms have evolved that
coordinate DNA unwinding with DNA synthesis and provide quality control measures prior to …
coordinate DNA unwinding with DNA synthesis and provide quality control measures prior to …
[HTML][HTML] Human NK cell deficiency as a result of biallelic mutations in MCM10
…, S Paust, MI Conte, RM Baxley… - The Journal of …, 2020 - Am Soc Clin Investig
Human natural killer cell deficiency (NKD) arises from inborn errors of immunity that lead to
impaired NK cell development, function, or both. Through the understanding of the biological …
impaired NK cell development, function, or both. Through the understanding of the biological …
[HTML][HTML] Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening
Minichromosome maintenance protein 10 (MCM10) is essential for eukaryotic DNA replication.
Here, we describe compound heterozygous MCM10 variants in patients with distinctive, …
Here, we describe compound heterozygous MCM10 variants in patients with distinctive, …
The insulator protein Suppressor of Hairy-wing is an essential transcriptional repressor in the Drosophila ovary
Suppressor of Hairy-wing [Su(Hw)] is a DNA-binding factor required for gypsy insulator
function and female germline development in Drosophila. The insulator function of the gypsy …
function and female germline development in Drosophila. The insulator function of the gypsy …
[PDF][PDF] FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination
Ubiquitination of proliferating cell nuclear antigen (PCNA) at lysine 164 (K164) activates DNA
damage tolerance pathways. Currently, we lack a comprehensive understanding of how …
damage tolerance pathways. Currently, we lack a comprehensive understanding of how …
Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary
AA Soshnev, B He, RM Baxley, N Jiang… - Nucleic acids …, 2012 - academic.oup.com
The Drosophila Suppressor of Hairy-wing [Su(Hw)] protein is a globally expressed, multi-zinc
finger (ZnF) DNA-binding protein. Su(Hw) forms a classic insulator when bound to the …
finger (ZnF) DNA-binding protein. Su(Hw) forms a classic insulator when bound to the …
RNF4 and USP7 cooperate in ubiquitin-regulated steps of DNA replication
DNA replication requires precise regulation achieved through post-translational modifications,
including ubiquitination and SUMOylation. These modifications are linked by the SUMO-…
including ubiquitination and SUMOylation. These modifications are linked by the SUMO-…