In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that
LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass …

Retinitis pigmentosa (RP) is a genetically heterogeneous disorder characterized by progressive
degeneration of the peripheral retina leading to night blindness and loss of visual fields. …

Alleles of the serotonin transporter gene (SERT) and the dopamine 4 receptor gene (DRD4)
were first associated with anxiety‐related and novelty‐seeking personality traits, respectively…

Africa, the ancestral home of all modern humans, is the most informative continent for
understanding the human genome and its contribution to complex disease. To better understand …

The cause of autosomal-dominant retinitis pigmentosa (adRP), which leads to loss of vision
and blindness, was investigated in families lacking a molecular diagnosis. A refined locus for …

… Eligible participants (in 43 centers across 16 countries) were randomly assigned separately
in a factorial design to aspirin 600 mg per day and/or RS 30 g per day, with placebo controls. …

Introduction: Impaired executive and memory function is a putative genetic trait marker of
bipolar I disorder (BPD I). Although executive/memory function has been posited to be an …

Huntington's disease (HD) correlates with abnormal expansion in a block of CAG repeats in
the Huntington's disease gene. We have investigated HD evolution by typing CAG alleles in …

… no effect of RS on colorectal cancer risk (HR, 0.92; 95% CI, 0.62–1.34; P = 0.63). There was
no interaction between aspirin and RS treatments. In conclusion, 30 g daily RS appears to …

We have identified a novel gene, transducin (β)–like 1 (TBL1), in the Xp22.3 genomic region,
that shows high homology with members of the WD-40–repeat protein family. The gene …