Class-V myosins, one of 15 known classes of actin-based molecular motors, have been
implicated in several forms of organelle transport 1 , 2 , 3 , 4 , 5 perhaps working with microtubule…

Myosin-V is a molecular motor that moves processively along its actin track. We have used
a feedback-enhanced optical trap to examine the stepping kinetics of this movement. By …

Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. To
carry out its cellular functions myosin VI moves toward the pointed end of actin, backward in …

Here we present a technique called single-molecule high-resolution colocalization (SHREC)
of fluorescent dyes that allows the measurement of interfluorophore distances in …

Background Mechanosensing governs many processes from molecular to organismal levels,
including during cytokinesis where it ensures successful and symmetrical cell division. …

Self-assembly of complex structures is commonplace in biology but often poorly understood.
In the case of the actin cytoskeleton, a great deal is known about the components that …

Through the coordinated action of diverse actin-binding proteins, cells simultaneously
assemble actin filaments with distinct architectures and dynamics to drive different processes. …

Eukaryotic cells organize their contents through trafficking along cytoskeletal filaments. The
leading edge of a typical metazoan cytoskeleton consists of a dense and complex …

Myosin VI is a molecular motor that can walk processively on actin filaments with a 36-nm
step size. The walking mechanism of myosin VI is controversial because it takes very large …

Proper tension maintenance in the cytoskeleton is essential for regulated cell polarity, cell
motility, and division. Non-muscle myosin IIB (NMIIB) generates tension along actin filaments …