Artificial intelligence in cancer imaging: clinical challenges and applications
…, LH Schwartz, RJ Gillies, RY Huang… - CA: a cancer journal …, 2019 - Wiley Online Library
Judgement, as one of the core tenets of medicine, relies upon the integration of multilayered
data with nuanced decision making. Cancer offers a unique context for medical decisions …
data with nuanced decision making. Cancer offers a unique context for medical decisions …
Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future …
Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …
cause of morbidity and mortality. In recent years there have been important advances in …
[HTML][HTML] Tumor-induced perturbations of cytokines and immune cell networks
Until recently, the intrinsically high level of cross-talk between immune cells, the complexity
of immune cell development, and the pleiotropic nature of cytokine signaling have hampered …
of immune cell development, and the pleiotropic nature of cytokine signaling have hampered …
Mechanisms and therapeutic implications of hypermutation in gliomas
…, GM Frampton, BM Alexander, RY Huang… - Nature, 2020 - nature.com
A high tumour mutational burden (hypermutation) is observed in some gliomas 1 , 2 , 3 , 4 –
5 ; however, the mechanisms by which hypermutation develops and whether it predicts the …
5 ; however, the mechanisms by which hypermutation develops and whether it predicts the …
Artificial intelligence augmentation of radiologist performance in distinguishing COVID-19 from pneumonia of other origin at chest CT
Background Coronavirus disease 2019 (COVID-19) and pneumonia of other diseases share
similar CT characteristics, which contributes to the challenges in differentiating them with …
similar CT characteristics, which contributes to the challenges in differentiating them with …
[HTML][HTML] Federated learning enables big data for rare cancer boundary detection
Although machine learning (ML) has shown promise across disciplines, out-of-sample
generalizability is concerning. This is currently addressed by sharing multi-site data, but such …
generalizability is concerning. This is currently addressed by sharing multi-site data, but such …
[HTML][HTML] Vegetarian diets and weight reduction: a meta-analysis of randomized controlled trials
RY Huang, CC Huang, FB Hu, JE Chavarro - Journal of general internal …, 2016 - Springer
Methods PubMed, EMBASE and UpToDate databases were searched through September 22,
2014, and investigators extracted data regarding study characteristics and assessed study …
2014, and investigators extracted data regarding study characteristics and assessed study …
Residual Convolutional Neural Network for the Determination of IDH Status in Low- and High-Grade Gliomas from MR Imaging
Purpose: Isocitrate dehydrogenase (IDH) mutations in glioma patients confer longer survival
and may guide treatment decision making. We aimed to predict the IDH status of gliomas …
and may guide treatment decision making. We aimed to predict the IDH status of gliomas …
Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer
RY Huang, A Francois, AJR McGray, A Miliotto… - …, 2017 - Taylor & Francis
Tumor-associated or -infiltrating lymphocytes (TALs or TILs) co-express multiple immune
inhibitory receptors that contribute to immune suppression in the ovarian tumor …
inhibitory receptors that contribute to immune suppression in the ovarian tumor …
[HTML][HTML] LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
RY Huang, C Eppolito, S Lele, P Shrikant, J Matsuzaki… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The immune co-inhibitory receptors lymphocyte activation gene-3 (LAG3) and programmed
cell death 1 (PD1) synergistically contribute to autoimmunity and tumor evasion. Here we …
cell death 1 (PD1) synergistically contribute to autoimmunity and tumor evasion. Here we …