… It is likely that ZIC3 plays a direct role in the establishment of the L–R axis, but it is difficult
to exclude the possibility that the observed L–R axis defects are secondary to earlier …

As the human genome project approaches completion, the challenge for mammalian geneticists
is to develop approaches for the systematic determination of mammalian gene function. …

We identified two novel mouse mutants with abnormal head-shaking behavior and neural
tube defects during the course of independent ENU mutagenesis experiments. The …

Circletail is one of only two mouse mutants that exhibit the most severe form of neural tube
defect (NTD), termed craniorachischisis. In this disorder, almost the entire brain and spinal …

The Zic genes encode zinc finger containing proteins that can bind proteins and DNA. The
understanding of Zic molecular networks has been hampered by functional redundancy …

Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapies including single-agent
immunotherapy and has a dense desmoplastic stroma, and most patients present with …

The generation of an embryonic body plan is the outcome of inductive interactions between
the progenitor tissues that underpin their specification, regionalization and morphogenesis. …

We have developed a sensitized screen to identify genes involved in gene silencing, using
random N-ethyl-N-nitrosourea mutagenesis on mice carrying a variegating GFP transgene. …

ATRX is an X-encoded member of the SNF2 family of ATPase/helicase proteins thought to
regulate gene expression by modifying chromatin at target loci. Mutations in ATRX provided …

The onset of X inactivation is preceded by a marked increase in the level of Xist RNA. Here
we demonstrate that increased stability of Xist RNA is the primary determinant of …