… Fry, Laura O'Regan, Sarah R. Sabir, Richard Bayliss; Cell cycle regulation by the NEK
family of protein kinases. J Cell Sci 1 October 2012; 125 (19): 4423–4433. doi: https://doi.org/…

Since the discovery of the fusion between EML4 (echinoderm microtubule associated
protein-like 4) and ALK (anaplastic lymphoma kinase), EML4-ALK, in lung adenocarcinomas in …

… A crucial contact at the interface of the two lobes is formed by R-spine residue 3 (RS3), a
side chain on the C-helix, and R-spine residue 2 (RS2). RS2 is also the central residue in a …

Aurora-A is an oncogenic kinase essential for mitotic spindle assembly. It is activated by
phosphorylation and by the microtubule-associated protein TPX2, which also localizes the …

We describe the crystal structure of a complex between importin-β residues 1–442 (Ib442)
and five FxFG nucleoporin repeats from Nsp1p. Nucleoporin FxFG cores bind on the convex …

The interaction between nuclear pore proteins (nucleoporins) and transport factors is crucial
for the translocation of macromolecules through nuclear pores. Many nucleoporins contain …

Some details of 544 episodes of infective endocarditis occurring in 541 patients during 1981
and 1982 are reported. The mean age of patients was 51.6 years and there was a greater …

The use of a partnering approach to deliver construction projects seeks to avoid the
confrontational setting where energy is used in a non-productive manner. Partnering calls for …

Background Anaplastic lymphoma kinase (ALK) inhibition using crizotinib has become the
standard of care in advancedALK-rearranged non-small cell lung cancer (NSCLC), but the …

Electrochemical intercalation of Mg 2+ into several compounds has been claimed,[14–16] yet
the clearest evidence of its feasibility has been provided for Mo 6S 8.[17, 18] This material …