[PDF][PDF] Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging
R Bogeska, AM Mikecin, P Kaschutnig, M Fawaz… - Cell stem cell, 2022 - cell.com
Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system following
injury, such as following infection or inflammation. These challenges impair HSC function, …
injury, such as following infection or inflammation. These challenges impair HSC function, …
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH),
potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we show …
potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we show …
[HTML][HTML] Somatic mutation rates scale with lifespan across mammals
…, MW Perkins, R Deaville, M Druce, R Bogeska… - Nature, 2022 - nature.com
The rates and patterns of somatic mutation in normal tissues are largely unknown outside of
humans 1 , 2 , 3 , 4 , 5 , 6 – 7 . Comparative analyses can shed light on the diversity of …
humans 1 , 2 , 3 , 4 , 5 , 6 – 7 . Comparative analyses can shed light on the diversity of …
Haematopoietic stem cells in perisinusoidal niches are protected from ageing
With ageing, intrinsic haematopoietic stem cell (HSC) activity decreases, resulting in
impaired tissue homeostasis, reduced engraftment following transplantation and increased …
impaired tissue homeostasis, reduced engraftment following transplantation and increased …
MPN patients harbor recurrent truncating mutations in transcription factor NF-E2
The molecular etiology of myeloproliferative neoplasms (MPNs) remains incompletely
understood, despite recent advances incurred through the discovery of several different mutations …
understood, despite recent advances incurred through the discovery of several different mutations …
A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2
…, T Hadlich, J Wehrle, M Gothwal, R Bogeska… - Journal of Experimental …, 2012 - rupress.org
The molecular pathophysiology of myeloproliferative neoplasms (MPNs) remains poorly
understood. Based on the observation that the transcription factor NF-E2 is often overexpressed …
understood. Based on the observation that the transcription factor NF-E2 is often overexpressed …
Continuous mitotic activity of primitive hematopoietic stem cells in adult mice
…, S Reinhardt, A Dahl, NS Anstee, R Bogeska… - Journal of Experimental …, 2020 - rupress.org
The proliferative activity of aging hematopoietic stem cells (HSCs) is controversially discussed.
Inducible fluorescent histone 2B fusion protein (H2B-FP) transgenic mice are important …
Inducible fluorescent histone 2B fusion protein (H2B-FP) transgenic mice are important …
The Fanconi anemia pathway is required for efficient repair of stress-induced DNA damage in haematopoietic stem cells
P Kaschutnig, R Bogeska, D Walter, A Lier… - Cell Cycle, 2015 - Taylor & Francis
Within regenerating tissues, aging is characterized by a progressive general deterioration of
organ function, thought to be driven by the gradual depletion of functional adult stem cells. …
organ function, thought to be driven by the gradual depletion of functional adult stem cells. …
Iron regulatory protein (IRP)–mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow
…, C Kalk, W Rüdiger, A Ertl, N Anstee, R Bogeska… - Science …, 2022 - science.org
Iron is mostly devoted to the hemoglobinization of erythrocytes for oxygen transport. However,
emerging evidence points to a broader role for the metal in hematopoiesis, including the …
emerging evidence points to a broader role for the metal in hematopoiesis, including the …
Hematopoietic stem cells fail to regenerate following inflammatory challenge
R Bogeska, P Kaschutnig, M Fawaz, AM Mikecin… - Biorxiv, 2020 - biorxiv.org
Hematopoietic stem cells (HSCs) are canonically defined by their capacity to maintain the
HSC pool via self-renewal divisions. However, accumulating evidence suggests that HSC …
HSC pool via self-renewal divisions. However, accumulating evidence suggests that HSC …