Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early secretory
antigenic target (ESAT6) protein family secretion (ESX) systems (also known as type VII …

Much effort has been spent trying to work out the origin and history of tuberculosis. Understanding
these concepts could have important consequences for the development of vaccines …

The 6kDa early secreted antigenic target from Mycobacterium tuberculosis, ESAT-6, is the
prototype of a novel family of small proteins of unknown function produced by Actinobacteria. …

As a result of an error during film output, Table 1 was published with some symbols missing.
The correct version can be found at http://www. sanger. ac. uk and is reproduced again here …

The distribution of 20 variable regions resulting from insertion-deletion events in the
genomes of the tubercle bacilli has been evaluated in a total of 100 strains of Mycobacterium …

New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the
synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of …

To understand the evolution, attenuation, and variable protective efficacy of bacillus
Calmette–Guérin (BCG) vaccines, Mycobacterium bovis BCG Pasteur 1173P2 has been subjected …

The highly successful human pathogen Mycobacterium tuberculosis has an extremely low
level of genetic variation, which suggests that the entire population resulted from clonal …

Although large human populations have been safely immunized against tuberculosis with
two live vaccines, Mycobacterium bovis BCG or Mycobacterium microti, the vole bacillus, the …

Survival within macrophages is a central feature of Mycobacterium tuberculosis pathogenesis.
Despite significant advances in identifying new immunological parameters associated …