Mild cognitive impairment (MCI), an intermediate state between normal aging and dementia,
is characterized by acquired cognitive deficits, without significant decline in functional …

Importance There are limited efficacious treatments for Alzheimer disease. Objective To assess
efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid …

The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic
pathways plays a key role in the generation of amyloid β peptide (Aβ) in Alzheimer disease. …

In spite of advances in neuroimaging and other brain biomarkers to assess preclinical
Alzheimer’s disease (AD), cognitive assessment has relied on traditional memory paradigms …

Background Neurofibrillary pathology has a stereotypical progression in Alzheimer's disease
(AD) that is encapsulated in the Braak staging scheme; however, some AD cases are …

Background Depression symptoms may be associated with the development of Alzheimer
disease (AD). Objectives To evaluate the association between depression symptoms and risk …

Objectives: It has been suggested in some studies that head injury is a risk factor for AD, and
that this risk is heightened among carriers of the APOE-ε4 allele. We examined the effects …

Objective This study aimed to determine the frequency of frontotemporal lobar degeneration
with ubiquitinated inclusions (FTLD‐U) in the setting of hippocampal sclerosis (HpScl) and …

After advanced age, having a parent affected with Alzheimer's disease (AD) is the most
significant risk factor for developing AD among cognitively normal (NL) individuals. Although rare …

Familial Alzheimer's disease (FAD) has been shown to be genetically heterogeneous, with
a very small proportion of early onset pedigrees being associated with mutations in the …