Prostaglandins, arachidonic acid, and inflammation

FA Kuehl Jr, RW Egan - Science, 1980 - science.org
The enzymatic oxidation of arachidonic acid has been shown to yield potent pathological
agents by two major pathways. Those of the prostaglandin (PG) pathway, particularly PGE 2 , …

MRI findings in Susac's syndrome

JO Susac, FR Murtagh, RA Egan, JR Berger, R Bakshi… - Neurology, 2003 - AAN Enterprises
Background: Susac syndrome (SS) is a self-limited syndrome, presumably autoimmune,
consisting of a clinical triad of encephalopathy, branch retinal artery occlusions, and hearing …

[HTML][HTML] Th2 cytokines and asthma the role of interleukin-5 in allergic eosinophilic disease

…, SP Umland, FM Cuss, RW Chapman, RW Egan - Respiratory …, 2001 - Springer
Interleukin-5 is produced by a number of cell types, and is responsible for the maturation
and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective …

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

…, A Pedan, MR Danzig, SP Umland, RW Egan… - Nature, 2002 - nature.com
Asthma is a common respiratory disorder characterized by recurrent episodes of coughing,
wheezing and breathlessness. Although environmental factors such as allergen exposure …

Metagenomic discovery of biomass-degrading genes and genomes from cow rumen

M Hess, A Sczyrba, R Egan, TW Kim, H Chokhawala… - Science, 2011 - science.org
The paucity of enzymes that efficiently deconstruct plant polysaccharides represents a major
bottleneck for industrial-scale conversion of cellulosic biomass into biofuels. Cow rumen …

[PDF][PDF] A landscape of pharmacogenomic interactions in cancer

…, H Chang, H de Silva, H Heyn, X Deng, RK Egan… - Cell, 2016 - cell.com
Systematic studies of cancer genomes have provided unprecedented insights into the
molecular nature of cancer. Using this information to guide the development and application of …

[HTML][HTML] MetaBAT 2: an adaptive binning algorithm for robust and efficient genome reconstruction from metagenome assemblies

DD Kang, F Li, E Kirton, A Thomas, R Egan, H An… - PeerJ, 2019 - peerj.com
We previously reported on MetaBAT, an automated metagenome binning software tool to
reconstruct single genomes from microbial communities for subsequent analyses of …

Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish

RJ Egan, CL Bergner, PC Hart, JM Cachat… - Behavioural brain …, 2009 - Elsevier
The zebrafish (Danio rerio) is emerging as a promising model organism for experimental
studies of stress and anxiety. Here we further validate zebrafish models of stress by analyzing …

[HTML][HTML] MetaBAT, an efficient tool for accurately reconstructing single genomes from complex microbial communities

DD Kang, J Froula, R Egan, Z Wang - PeerJ, 2015 - peerj.com
… | T P T P D | T + P R P D | R where T or R represent cases where two contigs are from … R
were chosen. In reality, P(T) is expected to be much bigger than P(R), thus we set P(T) = 10∗P(R

[HTML][HTML] Interleukin (IL)-10 inhibits nuclear factor кB (NFкB) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms (∗)

P Wang, P Wu, MI Siegel, RW Egan… - Journal of Biological …, 1995 - ASBMB
Our previous studies in human monocytes have demonstrated that interleukin (IL)-10 inhibits
lipopolysaccharide (LPS)-stimulated production of inflammatory cytokines, IL-1β, IL-6, IL-8, …