In somatic nuclei of female therian mammals, the two X chromosomes display very different
chromatin states: One X is typically euchromatic and transcriptionally active, and the other is …

… R. Galupa is funded by a PhD fellowship from DIM Biothérapies. We would like to dedicate
this article to Mary Lyon (1925–2014), who not only discovered XCI and contributed so much …

… potentials (Figure 1B) of range R with a hardcore repulsion at distance rHC. As no
measurements are available to constrain the values of R and rHC themselves, we adopted an …

Early in development, placental and marsupial mammals harbouring at least two X chromosomes
per nucleus are faced with a choice that affects the rest of their lives: which of those X …

… Domain dynamics clustering was performed using the R package Mfuzz (2.26.0) , using
as input the average Z-score per domain (row) in each stage from the 1-cell stage to the 64-cell …

… PCA on normalized data was performed with the FactoMineR R package (v1.33). … the hclust
function implemented in the gplots R package (v3.0.1). The limma R package (v3.28.4) was …

Accumulation of the Xist long noncoding RNA (lncRNA) on one X chromosome is the trigger
for X chromosome inactivation (XCI) in female mammals. Xist expression, which needs to be …

The mouse X-inactivation center (Xic) locus represents a powerful model for understanding
the links between genome architecture and gene regulation, with the non-coding genes Xist …

… Galupa et al. compared the potential of random sequences versus point mutations of
existing enhancers to generate new patterns of expression during Drosophila melanogaster …

… Galupa et al. uncover elements important for Xist regulation in its neighboring TAD and
reveal that these elements can influence gene regulation both within and between topological …