User profiles for R. Herwig

Ralf Herwig

Group Leader, Max Planck Institute for molecular Genetics, Berlin
Verified email at molgen.mpg.de
Cited by 43978

Cycloclasticus pugetii gen. nov., sp. nov., an Aromatic Hydrocarbon-Degrading Bacterium from Marine Sediments

…, JP Gray, RP Herwig… - … of Systematic and …, 1995 - microbiologyresearch.org
Three heterotrophic bacterial strains were isolated from different locations in Puget Sound,
Washington, by using biphenyl as the principal carbon source. These strains grow by using a …

The ConsensusPathDB interaction database: 2013 update

…, U Stelzl, H Lehrach, R Herwig - Nucleic acids …, 2013 - academic.oup.com
Abstract Knowledge of the various interactions between molecules in the cell is crucial for
understanding cellular processes in health and disease. Currently available interaction …

[BOOK][B] Systems biology in practice: concepts, implementation and application

E Klipp, R Herwig, A Kowald, C Wierling, H Lehrach - 2005 - books.google.com
Presenting the main concepts, this book leads students as well as advanced researchers
from different disciplines to an understanding of current ideas in the complex field of …

ConsensusPathDB: toward a more complete picture of cell biology

…, C Wierling, H Lehrach, R Herwig - Nucleic acids …, 2011 - academic.oup.com
ConsensusPathDB is a meta-database that integrates different types of functional interactions
from heterogeneous interaction data resources. Physical protein interactions, metabolic …

ConsensusPathDB—a database for integrating human functional interaction networks

…, C Wierling, H Lehrach, R Herwig - Nucleic acids …, 2009 - academic.oup.com
ConsensusPathDB is a database system for the integration of human functional interactions.
Current knowledge of these interactions is dispersed in more than 200 databases, each …

Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA

A Kamburov, R Cavill, TMD Ebbels, R Herwig… - …, 2011 - academic.oup.com
Pathway-level analysis is a powerful approach enabling interpretation of post-genomic data
at a higher level than that of individual biomolecules. Yet, it is currently hard to integrate …

Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Y Babaie, R Herwig, B Greber, TC Brink, W Wruck… - Stem …, 2007 - academic.oup.com
The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early
mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent …

Analyzing and interpreting genome data at the network level with ConsensusPathDB

R Herwig, C Hardt, M Lienhard, A Kamburov - Nature protocols, 2016 - nature.com
… conditions are computed; next, all ranks from pairs with positive differences R + and
negative differences R − are summed. The test statistic is the minimum of both rank sums: …

[HTML][HTML] DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro

…, H Gmuender, S Gotta, J Geraedts, R Herwig… - Scientific reports, 2019 - nature.com
Though clinical trials for medical applications of dimethyl sulfoxide (DMSO) reported toxicity
in the 1960s, later, the FDA classified DMSO in the safest solvent category. DMSO became …

[HTML][HTML] Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

…, I Kehler, A Fusi, T Kessler, R Herwig… - Nature …, 2017 - nature.com
Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours
responding to available therapies, requiring a better molecular understanding of the disease …