User profiles for R. Hoendorf

Robert Hoehndorf

King Abdullah University of Science and Technology
Verified email at kaust.edu.sa
Cited by 7480

Text-mining solutions for biomedical research: enabling integrative biology

…, A Oellrich, R Hoehndorf - Nature Reviews …, 2012 - nature.com
In response to the unbridled growth of information in literature and biomedical databases,
researchers require efficient means of handling and extracting information. As well as …

Semantic similarity and machine learning with ontologies

…, FZ Smaili, X Gao, R Hoehndorf - Briefings in …, 2021 - academic.oup.com
Ontologies have long been employed in the life sciences to formally represent and reason
over domain knowledge and they are employed in almost every major biological database. …

[HTML][HTML] The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

…, WH Liao, YW Liu, S Pascarelli, Y Frank, R Hoehndorf… - Genome biology, 2019 - Springer
Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global,
community-driven effort to evaluate and improve the computational annotation of protein …

DeepGO: predicting protein functions from sequence and interactions using a deep ontology-aware classifier

M Kulmanov, MA Khan, R Hoehndorf - Bioinformatics, 2018 - academic.oup.com
Motivation A large number of protein sequences are becoming available through the
application of novel high-throughput sequencing technologies. Experimental functional …

Mouse genetic and phenotypic resources for human genetics

PN Schofield, R Hoehndorf, GV Gkoutos - Human mutation, 2012 - Wiley Online Library
The use of model organisms to provide information on gene function has proved to be a
powerful approach to our understanding of both human disease and fundamental mammalian …

DeepGOPlus: improved protein function prediction from sequence

M Kulmanov, R Hoehndorf - Bioinformatics, 2020 - academic.oup.com
… Maxat Kulmanov, Robert Hoehndorf, DeepGOPlus: improved protein function prediction
from … per second using a single Intel(R) Xeon(R) E5-2680 CPU and Nvidia P6000 GPU. …

The role of ontologies in biological and biomedical research: a functional perspective

R Hoehndorf, PN Schofield… - Briefings in …, 2015 - academic.oup.com
Ontologies are widely used in biological and biomedical research. Their success lies in their
combination of four main features present in almost all ontologies: provision of standard …

[HTML][HTML] The Semanticscience Integrated Ontology (SIO) for biomedical research and knowledge discovery

…, MD Wilkinson, R Hoehndorf - Journal of biomedical …, 2014 - Springer
The Semanticscience Integrated Ontology (SIO) is an ontology to facilitate biomedical knowledge
discovery. SIO features a simple upper level comprised of essential types and relations …

[HTML][HTML] FoodOn: a harmonized food ontology to increase global food traceability, quality control and data integration

…, EJ Griffiths, GS Gosal, PL Buttigieg, R Hoehndorf… - npj Science of …, 2018 - nature.com
The construction of high capacity data sharing networks to support increasing government
and commercial data exchange has highlighted a key roadblock: the content of existing …

PhenomeNET: a whole-phenome approach to disease gene discovery

R Hoehndorf, PN Schofield… - Nucleic acids research, 2011 - academic.oup.com
… , where P is characterized by the ontology classes Cl(P) = P 1 ,...,P n and R is
characterized by the classes Cl(R) = R 1 ,...,R m , we define the similarity between P and R as: …