User profiles for R. J. McGorty
Ryan McGortyUniversity of San Diego Verified email at sandiego.edu Cited by 1902 |
Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics
The cytoskeleton is a dynamic network of proteins, including actin, microtubules, and their
associated motor proteins, that enables essential cellular processes such as motility, division, …
associated motor proteins, that enables essential cellular processes such as motility, division, …
Anomalous and heterogeneous DNA transport in biomimetic cytoskeleton networks
J Garamella, K Regan, G Aguirre, RJ McGorty… - Soft Matter, 2020 - pubs.rsc.org
The cytoskeleton, a complex network of protein filaments and crosslinking proteins, dictates
diverse cellular processes ranging from division to cargo transport. Yet, the role the …
diverse cellular processes ranging from division to cargo transport. Yet, the role the …
Active cytoskeletal composites display emergent tunable contractility and restructuring
The cytoskeleton is a model active matter system that controls processes as diverse as cell
motility and mechanosensing. While both active actomyosin dynamics and actin–microtubule …
motility and mechanosensing. While both active actomyosin dynamics and actin–microtubule …
Topology-dependent anomalous dynamics of ring and linear DNA are sensitive to cytoskeleton crosslinking
DM Wulstein, KE Regan, J Garamella, RJ McGorty… - Science …, 2019 - science.org
Cytoskeletal crowding plays a key role in the diffusion of DNA molecules through the cell,
acting as a barrier to effective intracellular transport and conformational stability required for …
acting as a barrier to effective intracellular transport and conformational stability required for …
Subtle changes in crosslinking drive diverse anomalous transport characteristics in actin–microtubule networks
SJ Anderson, J Garamella, S Adalbert, RJ McGorty… - Soft Matter, 2021 - pubs.rsc.org
Anomalous diffusion in crowded and complex environments is widely studied due to its
importance in intracellular transport, fluid rheology and materials engineering. Specifically, …
importance in intracellular transport, fluid rheology and materials engineering. Specifically, …
Cooperative Rheological State‐Switching of Enzymatically‐Driven Composites of Circular DNA And Dextran
J Marfai, RJ McGorty… - Advanced …, 2023 - Wiley Online Library
Polymer topology, which plays a principal role in the rheology of polymeric fluids, and non‐equilibrium
materials, which exhibit time‐varying rheological properties, are topics of intense …
materials, which exhibit time‐varying rheological properties, are topics of intense …
Quantifying cytoskeleton dynamics using differential dynamic microscopy
…, RM Robertson-Anderson, RJ McGorty - JoVE (Journal of …, 2022 - jove.com
Cells can crawl, self-heal, and tune their stiffness due to their remarkably dynamic cytoskeleton.
As such, reconstituting networks of cytoskeletal biopolymers may lead to a host of active …
As such, reconstituting networks of cytoskeletal biopolymers may lead to a host of active …
[HTML][HTML] Motor-driven advection competes with crowding to drive spatiotemporally heterogeneous transport in cytoskeleton composites
…, J Garamella, SK Kahl, BY Lee, RJ McGorty… - Frontiers in …, 2022 - frontiersin.org
The cytoskeleton–a composite network of biopolymers, molecular motors, and associated
binding proteins–is a paradigmatic example of active matter. Particle transport through the …
binding proteins–is a paradigmatic example of active matter. Particle transport through the …
Kinesin and myosin motors compete to drive rich multi-phase dynamics in programmable cytoskeletal composites
The cytoskeleton of biological cells relies on a diverse population of motors, filaments, and
binding proteins acting in concert to enable non-equilibrium processes ranging from mitosis …
binding proteins acting in concert to enable non-equilibrium processes ranging from mitosis …
Reconstituting and characterizing actin-microtubule composites with tunable motor-driven dynamics and mechanics
…, M Hendija, KA Lindsay, JL Ross, RJ McGorty… - JoVE (Journal of …, 2022 - jove.com
The composite cytoskeleton, comprising interacting networks of semiflexible actin filaments
and rigid microtubules, restructures and generates forces using motor proteins such as …
and rigid microtubules, restructures and generates forces using motor proteins such as …