Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in the
brain and spinal cord. This neurodegenerative syndrome shares pathobiological features …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have identified …

Semaphorins were initially characterized according to their role in repulsive axon guidance
but are now recognized as crucial regulators of morphogenesis and homeostasis over a …

An intronic GGGGCC repeat expansion in C9ORF72 is the most common cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the pathogenic …

Cerebral organoids are 3D stem cell-derived models that can be utilized to study the human
brain. The current consensus is that cerebral organoids consist of cells derived from the …

We conducted a genome-wide association study among 2,323 individuals with sporadic
amyotrophic lateral sclerosis (ALS) and 9,013 control subjects and evaluated all SNPs with P < …

This study evaluates the expression of the chemorepellent semaphorin III (D)/collapsin-1 (sema
III) following lesions to the rat CNS. Scar tissue, formed after penetrating injuries to the …

Members of the semaphorin family of secreted and transmembrane proteins utilize plexins
as neuronal receptors to signal repulsive axon guidance. It remains unknown how plexin …

Semaphorins constitute one of the largest families of repulsive and attractive growth cone
guidance proteins. They affect the growth cone’s actin cytoskeleton through interactions with …

Circular RNAs (circRNAs) are formed in all domains of life and via different mechanisms.
There has been an explosion in the number of circRNA papers in recent years; however, as a …