Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …

The fruit fly Drosophila melanogaster has emerged as a useful model for cardiac diseases,
both developmental abnormalities and adult functional impairment. Using the tools of both …

Insulin-IGF receptor (InR) signaling has a conserved role in regulating lifespan, but little is
known about the genetic control of declining organ function. Here, we describe progressive …

Population profiles of industrialized countries show dramatic increases in cardiovascular
disease with age, but the molecular and genetic basis of disease progression has been difficult …

Mitochondrial dysfunction plays important roles in many diseases, but there is no satisfactory
method to assess mitochondrial health in vivo. Here, we engineered a MitoTimer reporter …

Over the past century, research involving the fruit fly Drosophila melanogaster has consistently
yielded fundamental insights into the nature of complex organisms. The cardiovascular …

Reducing insulin/IGF signaling allows for organismal survival during periods of inhospitable
conditions by regulating the diapause state, whereby the organism stockpiles lipids, …

The epidemic of obesity and diabetes is causing an increased incidence of dyslipidemia-related
heart failure. While the primary etiology of lipotoxic cardiomyopathy is an elevation of …

The rapid life cycle and genetic tractability of Drosophila make it an ideal organism for large-scale
genetic screens. Here we describe a novel assay for pupal heart rate and rhythmicity, …

Exercise is among the most effective interventions for age-associated mobility decline and
metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity …