Cell death is a fundamental ingredient of life. Thus, not surprisingly more than one form of
cell death exists. Several excellent reviews on various forms of cell death have already been …

Oligonucleotide microarrays belong to the basic tools of molecular biology and allow for
simultaneous assessment of the expression level of thousands of genes. Analysis of microarray …

Age-related clonal hematopoiesis (CH) is a risk factor for malignancy, cardiovascular disease,
and all-cause mortality. Somatic mutations in DNMT3A are drivers of CH, but decades …

Purpose Following the nuclear accidents in Chernobyl and later in Fukushima, the nuclear
community has been faced with important issues concerning how to search for and diagnose …

During chronic infection, the inflammatory cytokine interferon gamma (IFNγ) damages
hematopoietic stem cells (HSCs) by disrupting quiescence and promoting excessive terminal …

Heat shock factor 1 (HSF1), a key regulator of transcriptional responses to proteotoxic stress,
was linked to estrogen (E2) signaling through estrogen receptor α (ERα). We found that an …

Background DNA microarrays are used for discovery of genes expressed differentially
between various biological conditions. In microarray experiments the number of analyzed …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy arising from T
lymphocyte precursors. We have previously shown by miRNA-seq, that miRNAs from the mir-…

… R) and applied it to our miRNA-seq data. Several aspects should be considered when
translating findings from miRNA-seq to an RT-qPCR experimental setting. The stability of miRNAs …

miRNAs form a class of noncoding RNAs, involved in post-transcriptional regulation of gene
expression, broadly studied for their involvement in physiological and pathological context. …