Adaptation to changes in extracellular tonicity is essential for cell survival. However, severe
or chronic hyperosmotic stress induces apoptosis, which involves cytochrome c (Cyt c) …

The integrated stress response (ISR) is a homeostatic mechanism induced by endoplasmic
reticulum (ER) stress. In acute/transient ER stress, decreased global protein synthesis and …

Pancreatic β-cells are prone to endoplasmic reticulum (ER) stress due to their role in insulin
secretion. They require sustainable and efficient adaptive stress responses to cope with this …

The RNA binding protein DAZL is essential for gametogenesis, but its direct in vivo functions,
RNA targets, and the molecular basis for germ cell loss in Dazl-null mice are unknown. …

Recent genome-wide studies have revealed the presence of thousands of long non-protein-coding
RNAs (lncRNAs), some of which may play critical roles in the cell. We have …

ESD may be a serious threat to electronic devices and systems. The intensity of ESD can
vary strongly in spite of constant charge voltage. The bad reproducibility of ESD is notorious. …

… We have shown that protein kinase R (PKR) promotes the nuclear localization of Serine-536
phosphorylated NF-kB family member p65, which leads to an increase in inflammatory …

Computer simulation of electrostatic discharge (ESD) for simplified objects is described and
compared to measured transient fields of human/metal ESD. The simulation algorithm uses …

The integrated stress response (ISR) plays a pivotal role in adaptation of translation
machinery to cellular stress. Here, we demonstrate an ISR-independent osmoadaptation …

GADD34, a stress-induced regulatory subunit of the phosphatase PP1, is known to function
in hyperosmotic stress through its well-known role in the integrated stress response (ISR) …