Seizures in patients presenting with mesial temporal lobe epilepsy result from the interaction
among neuronal networks in limbic structures such as the hippocampus, amygdala and …

Animal models have provided invaluable data for identifying the pathogenesis of epileptic
disorders. Clearly, the relevance of these experimental findings would be strengthened by the …

… Timo Kirschstein and Rüdiger Köhling have no conflicts of interest in relation to this article. …
Rüdiger Köhling … 70.?lectroenc?phalographie en r?animation …

Astrocytic gap junctions have been suggested to contribute to spatial buffering of potassium
in the brain. Direct evidence has been difficult to gather because of the lack of astrocyte-…

Application of 4-aminopyridine (4AP, 50 μm) to combined slices of adult rat hippocampus–entorhinal
cortex-induced ictal and interictal epileptiform discharges, as well as slow field …

The cellular and network mechanisms of the transition of brief interictal discharges to prolonged
seizures are a crucial issue in epilepsy. Here we used hippocampal slices exposed to …

Patients with Taylor’s type focal cortical dysplasia (FCD) present with seizures that are often
medically intractable. Here, we attempted to identify the cellular and pharmacological …

… A part of this work has been published in abstract form (Köhling et al., 1995b). … They were
placed in a portable incubation chamber (Köhling et al., 1996) with oxygenated (95% O2, 5% …

Low-voltage fast (LVF) and hypersynchronous (HYP) patterns are the seizure-onset patterns
most frequently observed in intracranial EEG recordings from mesial temporal lobe epilepsy …

Animal experiments, and particularly functional investigations on human chronically epileptic
tissue as well as genetic studies in epilepsy patients and their families strongly suggest that …