▪ Abstract Although initially recognized as a handy tool to reduce gene expression, RNA
silencing, triggered by double-stranded RNA molecules, is now recognized as a mechanism for …

… been observed for RsAgo 8 , but it co-occurs with a predicted nuclease in R. sphaeroides. …
not in R. sphaeroides; however, it does interfere with plasmid-encoded RNA in R. sphaeroides …

Small non-coding RNAs, through association with Argonaute protein family members, have
a variety of functions during the development of an organism. Although there is increased …

Mature microRNAs (miRNAs) are generated via a two-step processing pathway to yield ∼22-nucleotide
small RNAs that regulate gene expression at the post-transcriptional level 1 . …

… In fact, we have found that at least one other gene required for RNAi (mut-15; RF Ketting
and RHA Plasterk, unpubl.) displays such a maternal effect. It was expected that maternally …

Piwi proteins specify an animal-specific subclass of the Argonaute family that, in vertebrates,
is specifically expressed in germ cells. We demonstrate that zebrafish Piwi (Ziwi) is …

… René F Ketting René F Ketting … elegans (R. Koch et al., personal communication) and
identified the gene by sequencing candidate genes. As shown in Figure 5, two mut-7 alleles, …

RNA interference (RNAi) regulates gene expression by the cleavage of messenger RNA, by
mRNA degradation and by preventing protein synthesis. These effects are mediated by a …

Several vertebrate microRNAs (miRNAs) have been implicated in cellular processes such as
muscle differentiation, synapse function, and insulin secretion. In addition, analysis of Dicer …

The Piwi proteins of the Argonaute superfamily are required for normal germline development
in Drosophila, zebrafish, and mice and associate with 24–30 nucleotide RNAs termed …