CopraRNA and IntaRNA: predicting small RNA targets, networks and interaction domains

…, S Lott, R Kleinkauf, WR Hess, R Backofen - Nucleic acids …, 2014 - academic.oup.com
CopraRNA (Comparative prediction algorithm for small RNA targets) is the most recent asset
to the Freiburg RNA Tools webserver. It incorporates and extends the functionality of the …

Freiburg RNA tools: a central online resource for RNA-focused research and teaching

…, S Heyne, M Hiller, K Kundu, R Kleinkauf… - Nucleic acids …, 2018 - academic.oup.com
The Freiburg RNA tools webserver is a well established online resource for RNA-focused
research. It provides a unified user interface and comprehensive result visualization for …

antaRNA: ant colony-based RNA sequence design

R Kleinkauf, M Mann, R Backofen - Bioinformatics, 2015 - academic.oup.com
… Robert Kleinkauf , Robert Kleinkauf … In a final step, the length-normalized base pair
distance d s t r between P sol and the compiled target structure P C is determined. …

[HTML][HTML] antaRNA–Multi-objective inverse folding of pseudoknot RNA using ant-colony optimization

R Kleinkauf, T Houwaart, R Backofen, M Mann - BMC bioinformatics, 2015 - Springer
Background Many functional RNA molecules fold into pseudoknot structures, which are often
essential for the formation of an RNA’s 3D structure. Currently the design of RNA molecules…

The numerical computation of homoclinic orbits for maps

WJ Beyn, JM Kleinkauf - SIAM journal on numerical analysis, 1997 - SIAM
… where V ⊂ R k is a sufficiently small neighborhood of 0. By definition these sets are positive
and negative invariant… Then for given z J and rR … We always use the Euclidean norm in R

A nonribosomal system of peptide biosynthesis

H Kleinkauf, H Von Döhren - European Journal of Biochemistry, 1996 - Wiley Online Library
This review covers peptide structures originating from the concerted action of enzyme systems
without the direct participation of nucleic acids. Biosynthesis proceeds by formation of …

Nonribosomal biosynthesis of peptide antibiotics

H Kleinkauf, H von DÖHREN - European Journal of …, 1990 - Wiley Online Library
… P represents a peptide chain, R is an acyl residue at the amino terminal, C a cyclopeptide,
L is a lactone, D is a depsipeptide (alternating peptide and ester bonds, or more than one …

[HTML][HTML] Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis.

…, E Schneider-Scherzer, H Kleinkauf, R Zocher - Journal of Biological …, 1994 - Elsevier
… Whereas first insights into the biosynthetic pathways of ( 4 R)-4-[(E)-2-butenyl3-4-methyl-~-threonine
B (50 m HEPES, pH 8.5,4 m EDTA, 20 m dithiothreitol, and 50 p have pyridoxal …

[HTML][HTML] A highly specific D-hydroxyisovalerate dehydrogenase from the enniatin producer Fusarium sambucinum.

C Lee, H Görisch, H Kleinkauf, R Zocher - Journal of biological chemistry, 1992 - Elsevier
A highly specific D-hydroxyisovalerate (D-HIV) dehydrogenase, which is a key enzyme in
depsipeptide synthesis, was purified to near homogeneity from the enniatin-producing fungus …

[HTML][HTML] Mechanism of cyclosporin A biosynthesis. Evidence for synthesis via a single linear undecapeptide precursor.

J Dittmann, RM Wenger, H Kleinkauf… - Journal of Biological …, 1994 - Elsevier
… Four intermediate peptides of the growing (Kleinkauf and von Dohren, 1987). According to
… A were The costs of publication of this article were defrayed in part by the R. Traber, Sandoz …