Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
…, F Giulianini, EG Holliday, AU Jackson, R Li-Gao… - Nature …, 2018 - nature.com
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease.
We report the largest genetic association study of blood pressure traits (systolic, diastolic …
We report the largest genetic association study of blood pressure traits (systolic, diastolic …
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …
Genome-wide associations for birth weight and correlations with adult disease
…, R Li-Gao, TS Ahluwalia, E Kreiner, R Rueedi… - Nature, 2016 - nature.com
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …
observational studies is reproducibly associated with future risk of adult metabolic diseases …
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
…, JP Bradfield, N Grarup, MN Kooijman, R Li-Gao… - Nature …, 2019 - nature.com
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
…, M Müller-Nurasyid, K Meidtner, R Li-Gao… - Nature …, 2018 - nature.com
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …
Hierarchical NiCo 2 O 4 nanosheets@ hollow microrod arrays for high-performance asymmetric supercapacitors
Novel hierarchical NiCo2O4 nanosheets@hollow microrod arrays (NSs@HMRAs) are fabricated
by a simple and environmental friendly template-assisted electrodeposition followed by …
by a simple and environmental friendly template-assisted electrodeposition followed by …
The trans-ancestral genomic architecture of glycemic traits
…, M Horikoshi, TS Boutin, R Mägi, J Waage, R Li-Gao… - Nature …, 2021 - nature.com
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health.
To date, most genetic studies of glycemic traits have focused on individuals of European …
To date, most genetic studies of glycemic traits have focused on individuals of European …
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
…, N Shah, C Oldmeadow, P Almgren, R Li-Gao… - Nature …, 2019 - nature.com
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood
pressure to identify genes, tissues, phenomes and medication contexts of blood pressure …
pressure to identify genes, tissues, phenomes and medication contexts of blood pressure …
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
The genetic architecture of human reproductive behavior—age at first birth (AFB) and number
of children ever born (NEB)—has a strong relationship with fitness, human development, …
of children ever born (NEB)—has a strong relationship with fitness, human development, …
[PDF][PDF] Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects
…, MC Zillikens, C Langenberg, R Li-Gao… - The American Journal of …, 2018 - cell.com
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children,
total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar …
total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar …