User profiles for R. Lieshout

Ryan J Van Lieshout

Associate Professor, McMaster University
Verified email at mcmaster.ca
Cited by 6337

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 6 …

…, N Jaworska, M Steiner, RJV Lieshout… - The Canadian …, 2016 - journals.sagepub.com
Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted
a revision of the 2009 guidelines by updating the evidence and recommendations. The …

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

…, S Dietmann, SE Davies, RK Praseedom, R Lieshout… - Nature medicine, 2017 - nature.com
Human liver cancer research currently lacks in vitro models that can faithfully recapitulate
the pathophysiology of the original tumor. We recently described a novel, near-physiological …

Directiveness in teachers' language input to toddlers and preschoolers in day care

L Girolametto, E Weitzman, R Lieshout, D Duff - Journal of Speech …, 2000 - ASHA
Five subtypes of directiveness were examined in the interactions of day care teachers with
toddler and preschooler groups. The instructional context (book reading, play dough) yielded …

[HTML][HTML] Cancer-associated fibroblasts provide a stromal niche for liver cancer organoids that confers trophic effects and therapy resistance

…, L Wang, M Li, Z Ge, L Noordam, R Lieshout… - Cellular and molecular …, 2021 - Elsevier
Background & Aims Cancer-associated fibroblasts (CAFs) play a key role in the cancer
process, but the research progress is hampered by the paucity of preclinical models that are …

From organoids to organs: Bioengineering liver grafts from hepatic stem cells and matrix

J Willemse, R Lieshout, LJW van der Laan… - Best practice & research …, 2017 - Elsevier
Due to the complex function and structure of the liver, resourceful solutions for treating end-stage
liver disease are required. Currently, liver transplantation is the only curative …

Measuring the size of an airport's catchment area

R Lieshout - Journal of Transport Geography, 2012 - Elsevier
… Access time costs are therefore represented as follows:(7) access time costs r , x = access
time r , x · VoTT m where access time r,x is the access time between hinterland region r and …

Experimental models to unravel the molecular pathogenesis, cell of origin and stem cell properties of cholangiocarcinoma

S Vicent, R Lieshout, A Saborowski… - Liver …, 2019 - Wiley Online Library
Human cholangiocarcinoma (CCA) is an aggressive tumour entity arising from the biliary
tree, whose molecular pathogenesis remains largely undeciphered. Over the last decade, the …

Large‐scale production of LGR5‐positive bipotential human liver stem cells

…, ME Van Wolferen, G Van Tienderen, R Lieshout… - …, 2020 - Wiley Online Library
Background and Aims The gap between patients on transplant waiting lists and available
donor organs is steadily increasing. Human organoids derived from leucine‐rich repeat‐…

Patterns of adult-child linguistic interaction in integrated day care groups

…, L Hoaken, E Weitzman, R Lieshout - Language, speech, and …, 2000 - ASHA
Purpose: This study investigated the language input of eight childcare providers to children
with developmental disabilities, including language delay, who were integrated into …

The competitive landscape of air transport in Europe

R Lieshout, P Malighetti, R Redondi… - Journal of Transport …, 2016 - Elsevier
… level in municipality r, for passengers with travel motive m, and pax r , x , y is the amount
of passengers travelling between municipality r via departure airport x to destination y. …