User profiles for R. Lo
 | Roger S. Lo, MD., PhDProfessor of Medicine, Molecular and Medical Pharmacology Verified email at mednet.ucla.edu Cited by 35496 |
[HTML][HTML] TGFβ signaling in growth control, cancer, and heritable disorders
J Massagué, SW Blain, RS Lo - Cell, 2000 - cell.com
… phosphorylates a member of the R-Smad class (Smads1, 2, 3, 5… Receptor-mediated
phosphorylation of a R-Smad decreases … The MH1 and MH2 domains are conserved in all …
phosphorylation of a R-Smad decreases … The MH1 and MH2 domains are conserved in all …
Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a …
…, M Lucas, R Geuskens, RS Barros, R Dobbe… - The Lancet …, 2019 - thelancet.com
Background CT perfusion (CTP) and diffusion or perfusion MRI might assist patient selection
for endovascular thrombectomy. We aimed to establish whether imaging assessments of …
for endovascular thrombectomy. We aimed to establish whether imaging assessments of …
[HTML][HTML] Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway
…, V Lunardi, D Franceschini, A Pagetta, R Lo… - Journal of …, 2019 - Springer
Background Neuroinflammation is the response of the central nervous system to events that
interfere with tissue homeostasis and represents a common denominator in virtually all …
interfere with tissue homeostasis and represents a common denominator in virtually all …
[HTML][HTML] A randomized trial of intraarterial treatment for acute ischemic stroke
…, LC van Dijk, LJ Kappelle, RH Lo… - … England Journal of …, 2015 - Mass Medical Soc
Background In patients with acute ischemic stroke caused by a proximal intracranial arterial
occlusion, intraarterial treatment is highly effective for emergency revascularization. However…
occlusion, intraarterial treatment is highly effective for emergency revascularization. However…
Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation
… In cell survival assays, M229 R, M238 R and M249 R sub-lines displayed strong resistance
… Morphologically, both M229 R and M238 R sub-lines appear flatter and more fibroblast-like …
… Morphologically, both M229 R and M238 R sub-lines appear flatter and more fibroblast-like …
PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes
Motivation: PSORTb has remained the most precise bacterial protein subcellular localization
(SCL) predictor since it was first made available in 2003. However, the recall needs to be …
(SCL) predictor since it was first made available in 2003. However, the recall needs to be …
[HTML][HTML] Mutations associated with acquired resistance to PD-1 blockade in melanoma
…, J Saco, B Homet Moreno, R Mezzadra… - … England Journal of …, 2016 - Mass Medical Soc
Background Approximately 75% of objective responses to anti–programmed death 1 (PD-1)
therapy in patients with melanoma are durable, lasting for years, but delayed relapses have …
therapy in patients with melanoma are durable, lasting for years, but delayed relapses have …
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database
…, AN Sharma, S Doshi, M Courtot, R Lo… - Nucleic acids …, 2016 - academic.oup.com
The Comprehensive Antibiotic Resistance Database (CARD; http://arpcard.mcmaster.ca ) is
a manually curated resource containing high quality reference data on the molecular basis …
a manually curated resource containing high quality reference data on the molecular basis …
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
R Straussman, T Morikawa, K Shee, M Barzily-Rokni… - Nature, 2012 - nature.com
Drug resistance presents a challenge to the treatment of cancer patients. Many studies have
focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that …
focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that …
[PDF][PDF] Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
… tumor groups were defined by GSVA score differences of R 10% and FDR-corrected, twosided …
We also collected gene sets that met the GSVA score differences of R 10% and nominal …
We also collected gene sets that met the GSVA score differences of R 10% and nominal …