The use of antibiotics is threatened by the emergence and spread of multidrug-resistant
strains of bacteria. Thus, there is a need to develop antibiotics that address new targets. In this …

Most bacteria and archaea use the tubulin homologue FtsZ as its central organizer of cell
division. In Gram-negative Escherichia coli bacteria, FtsZ recruits cytosolic, transmembrane, …

The 5′-hydroxymethyl metabolite of the penicillin based antibiotic flucloxacillin (FLX) is
considered to be involved in bile duct damage occurring in a small number of patients. Because …

CYP130 belongs to the subset of cytochrome P450s from Mycobacterium tuberculosis (Mtb)
that have been structurally characterized. Despite several efforts for its functional …

In this work, parameters are optimized for a charge‐on‐spring based polarizable force field
for linear alcohols. We show that parameter transferability can be obtained using a …

… According to Equation 1 the slope of the linear plot obtained equals the negative value of
the activation energy E a divided by the gas constant R. The pre-exponential factor A …

Autotransporters are the core component of a molecular nano-machine that delivers cargo
proteins across the outer membrane of Gram-negative bacteria. Part of the type V secretion …

The carotid sinus syndrome (CSS) is characterized by repetitive syncope due to prolonged
heart rate slowing or a profound drop in systolic blood pressure. CSS is due to an …

Autotransporters are large virulence factors secreted by Gram-negative bacteria. They are
synthesized with a C-terminal domain that forms a β-barrel pore in the outer membrane …

Outer membrane vesicles (OMVs) are spherical nanoparticles that naturally shed from Gram-negative
bacteria. They are rich in immunostimulatory proteins and lipopolysaccharide but …