Chromosome 21 and down syndrome: from genomics to pathophysiology

SE Antonarakis, R Lyle, ET Dermitzakis… - Nature reviews …, 2004 - nature.com
The sequence of chromosome 21 was a turning point for the understanding of Down
syndrome. Comparative genomics is beginning to identify the functional components of the …

Molecular regulation of adipocyte differentiation

RM Cowherd, RE Lyle, RE McGehee Jr - Seminars in cell & developmental …, 1999 - Elsevier
Significant advances have been made recently toward understanding the molecular events
that regulate adipocyte differentiation.In vitromodels of adipogenesis, such as the 3T3-L1 …

Qualitative research in family therapy: A substantive and methodological review

DR Gehart, DA Ratliff, RR Lyle - Journal of marital and family …, 2001 - Wiley Online Library
Over the last decade, marriage and family therapy (MFT) researchers have developed a
growing interest in qualitative research. In this article, we review substantive and …

A performance test for assessment of upper limb function in physical rehabilitation treatment and research

RC Lyle - International journal of rehabilitation research, 1981 - journals.lww.com
… Goodkin, R., & Diller, R. Reliability among physical therapists in diagnosis and treatment of
Lyle, RC Functional assessment and biofeedback treatment of the upper limb in hemiplegia. …

[HTML][HTML] Genome-wide associations of gene expression variation in humans

…, AG Clark, MJ Minichiello, S Deutsch, R Lyle… - PLoS …, 2005 - journals.plos.org
… Based on the adjusted r 2 values from the linear regression performed for the SNPs with
the lowest p-values (cis or trans), we have more than 80% power to detect effects of r 2 ≥ 0.50 …

[HTML][HTML] Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells

…, C Baer, F Burdet, C Maderna, GD Gilfillan, R Lyle… - Cell reports, 2014 - cell.com
MicroRNA (miRNA) transfer via exosomes may mediate cell-to-cell communication. Interestingly,
specific miRNAs are enriched in exosomes in a cell-type-dependent fashion. However, …

Analysis of the tandem repeat locus D4Z4 associated with facioscapulohumeral muscular dystropothhy

JE Hewitt, R Lyle, LN Clark, EM Valleley… - Human molecular …, 1994 - academic.oup.com
The sequence of the tandem repeat sequence (D4Z4) associated with facioscapulohumeral
muscular dystrophy (FSHD) has been determined: each copy of the 3.3 kb repeat contains …

Peak bone mass in young women

…, BR Martin, J Zhao, GP Mccabe, RM Lyle… - Journal of Bone and …, 2020 - academic.oup.com
Increasing peak bone mineral density (BMD) or content (BMC) in young women may help to
reduce the incidence of osteoporosis. Identifying the age when peak bone content or …

Increasing prevalence of medically complex children in US hospitals

KH Burns, PH Casey, RE Lyle, TM Bird, JJ Fussell… - …, 2010 - publications.aap.org
OBJECTIVE: In this study we used national data to determine changes in the prevalence of
hospital admissions for medically complex children over a 15-year period. PATIENTS AND …

[HTML][HTML] Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

R Lyle, F Béna, S Gagos, C Gehrig, G Lopez… - European Journal of …, 2009 - nature.com
… carried out in Excel (Microsoft Corporation), and statistics and graphing in R (www.R-project.org). …
Calculations were carried out in Excel (Microsoft Corporation) and graphing in R (www.…