An acute ischaemic stroke is due to the sudden blockage of an intracranial blood vessel by
an embolized thrombus. In the context of setting up in silico trials for the treatment of acute …

The advancement of ischaemic stroke treatment relies on resource-intensive experiments
and clinical trials. In order to improve ischaemic stroke treatments, such as thrombolysis and …

An in silico trial simulates a disease and its corresponding therapies on a cohort of virtual
patients to support the development and evaluation of medical devices, drugs, and treatment. …

Computational physiological models are promising tools to enhance the design of clinical
trials and to assist in decision making. Organ-scale haemodynamic models are gaining …

… found in Padmos et al., 2021 [22]. The Young's modulus for all cerebral vessels is set to 1.6
MPa. … RM Padmos wrote the manuscript and developed the computational model. N. Arrarte …

The presence of collaterals and high thrombus permeability are associated with good functional
outcomes after an acute ischaemic stroke. We aim to understand the combined effect of …

2. Methods A continuum model of the brain requires a sufficiently detailed geometrical description
of the characteristic surface and volume regions. Here, a patient-specific volume mesh …

Accurately predicting brain tissue perfusion and infarct volume after an acute ischaemic
stroke requires the two-way coupling of perfusion models on multiple scales. We present a …

Predicting infarct volume is necessary to develop in silico trials for the treatment of acute
ischaemic stroke. This requires modelling of blood flow across length scales incorporating three …

Every year, millions of people suffer a stroke, often resulting in disability or death. Stroke is
currently the second leading cause of death worldwide. Stroke survivors are often chronically …