Coronaviruses have exceptionally large RNA genomes of approximately 30 kilobases. Genome
replication and transcription is mediated by a multisubunit protein complex comprised of …

Coronavirus genome replication is mediated by a multi-subunit protein complex that is
comprised of more than a dozen virally encoded and several cellular proteins. Interactions of the …

Coronaviruses (CoV) and picornaviruses are plus-strand RNA viruses that use 5′ cap-dependent
and cap-independent strategies, respectively, for viral mRNA translation initiation. …

Sequence analyses of RNA virus genomes remain challenging owing to the exceptional
genetic plasticity of these viruses. Because of high mutation and recombination rates, genome …

RNA-dependent RNA polymerases (RdRps) of the Nidovirales (Coronaviridae, Arteriviridae,
and 12 other families) are linked to an amino-terminal (N-terminal) domain, called NiRAN, …

Abstract Structure predictions suggest a partial conservation of RNA structure elements in
coronavirus terminal genome regions. Here, we determined the structures of stem-loops (SL) 1 …

Coronavirus nonstructural protein 8 (nsp8) has been suggested to have diverse activities,
including noncanonical template-dependent polymerase activities. Here, we characterized a …

Inhibition of coronavirus (CoV)‐encoded papain‐like cysteine proteases (PL pro ) represents
an attractive strategy to treat infections by these important human pathogens. Herein we …

The influenza A virus (IAV) polymerase is a multifunctional machine that can adopt alternative
configurations to perform transcription and replication of the viral RNA genome in a …

… For R g values, error bars correspond to the SD of the experimental data from the fit of the
linear Guinier region plus the SD of R g values from all possible intervals from the R g values …